PPFIA4

Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
Identifiers
Symbol	PPFIA4
External IDs	OMIM: 603145 MGI: 1915757 HomoloGene: 66200 GeneCards: PPFIA4 Gene
Gene ontology Molecular function • protein binding Cellular component • intracellular • cytosol • cell surface • synapse • presynaptic active zone Biological process • synaptic transmission • neurotransmitter secretion • glutamate secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8497	68507
Ensembl	ENSG00000143847	ENSMUSG00000026458
UniProt	O75335	B8QI36
RefSeq (mRNA)	NM_001304331	NM_001144855.1
RefSeq (protein)	NP_001291260	NP_001138327.1
Location (UCSC)	Chr 1: 203.03 – 203.08 Mb	Chr 1: 136.19 – 136.23 Mb
PubMed search

Liprin-alpha-4 is a protein that in humans is encoded by the PPFIA4 gene.^[1][2]

Interactions

PPFIA4 has been shown to interact with:

• ERC2,^[3]
• GIT1,^[3][4] and
• Nuclear receptor coactivator 2.^[5]

References

1. Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J Biol Chem 273 (25): 15611–20. doi:10.1074/jbc.273.25.15611. PMID 9624153.
2. "Entrez Gene: PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4".
3. Ko J, Na M, Kim S, Lee JR, Kim E (Oct 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
4. Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (Mar 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. PMID 12629171.
5. Wyszynski M, Kim E, Dunah AW, Passafaro M, Valtschanoff JG, Serra-Pagès C, Streuli M, Weinberg RJ, Sheng M (Mar 2002). "Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting". Neuron 34 (1): 39–52. doi:10.1016/s0896-6273(02)00640-2. PMID 11931740.

Further reading

• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Millar JK, Christie S, Porteous DJ (2004). "Yeast two-hybrid screens implicate DISC1 in brain development and function.". Biochem. Biophys. Res. Commun. 311 (4): 1019–25. doi:10.1016/j.bbrc.2003.10.101. PMID 14623284.
• Katoh M, Katoh M (2004). "Identification and characterization of human PPFIA4 gene in silico.". Int. J. Mol. Med. 12 (6): 1009–14. doi:10.3892/ijmm.12.6.1009. PMID 14612982.
• Ko J, Na M, Kim S, Lee JR, Kim E (2004). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins.". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
• Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting.". J. Neurosci. 23 (5): 1667–77. PMID 12629171.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.