PPP2CB

Protein phosphatase 2, catalytic subunit, beta isozyme
PDB rendering based on 2iae.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2iae​, 2ie3​, 2ie4​, 2npp​, 2nyl​, 2nym​
Identifiers
Symbols	PPP2CB ; PP2Abeta; PP2CB
External IDs	OMIM: 176916 MGI: 1321161 HomoloGene: 37889 ChEMBL: 2435 GeneCards: PPP2CB Gene
EC number	3.1.3.16
Gene ontology Molecular function • protein serine/threonine phosphatase activity • protein binding • protein C-terminus binding • metal ion binding Cellular component • protein phosphatase type 2A complex • chromosome, centromeric region • spindle pole • nucleus • cytosol • extracellular exosome Biological process • protein dephosphorylation • fibroblast growth factor receptor signaling pathway • apoptotic mitochondrial changes • regulation of gene expression • response to endoplasmic reticulum stress • response to hydrogen peroxide • proteasome-mediated ubiquitin-dependent protein catabolic process • negative regulation of Ras protein signal transduction • response to antibiotic Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5516	19053
Ensembl	ENSG00000104695	ENSMUSG00000009630
UniProt	P62714	P62715
RefSeq (mRNA)	NM_001009552	NM_017374
RefSeq (protein)	NP_001009552	NP_059070
Location (UCSC)	Chr 8: 30.77 – 30.81 Mb	Chr 8: 33.6 – 33.62 Mb
PubMed search

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform is an enzyme that in humans is encoded by the PPP2CB gene.^[1]

Function

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. Two transcript variants encoding the same protein have been identified for this gene.^[2]

Interactions

PPP2CB has been shown to interact with TLX1,^[3] PPP2R1B^[4] and PPP2R1A.^[4][5]

See also

PPP2CA

References

1. Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PT (April 1993). "Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively". Cytogenetics and Cell Genetics 63 (1): 35–41. doi:10.1159/000133497. PMID 8383590.
2. "Entrez Gene: PPP2CB protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform".
3. Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature 385 (6615): 454–8. doi:10.1038/385454a0. PMID 9009195.
4. Zhou J, Pham HT, Ruediger R, Walter G (Jan 2003). "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". The Biochemical Journal 369 (Pt 2): 387–98. doi:10.1042/BJ20021244. PMC 1223084. PMID 12370081.
5. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

Further reading

• Zolnierowicz S (Oct 2000). "Type 2A protein phosphatase, the complex regulator of numerous signaling pathways". Biochemical Pharmacology 60 (8): 1225–35. doi:10.1016/S0006-2952(00)00424-X. PMID 11007961.
• Goedert M, Cohen ES, Jakes R, Cohen P (Nov 1992). "p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]". FEBS Letters 312 (1): 95–9. doi:10.1016/0014-5793(92)81418-L. PMID 1330687.
• Khew-Goodall Y, Mayer RE, Maurer F, Stone SR, Hemmings BA (Jan 1991). "Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes". Biochemistry 30 (1): 89–97. doi:10.1021/bi00215a014. PMID 1846293.
• Pallas DC, Shahrik LK, Martin BL, Jaspers S, Miller TB, Brautigan DL, Roberts TM (Jan 1990). "Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A". Cell 60 (1): 167–76. doi:10.1016/0092-8674(90)90726-U. PMID 2153055.
• Virshup DM, Kauffman MG, Kelly TJ (Dec 1989). "Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A". The EMBO Journal 8 (12): 3891–8. PMC 402079. PMID 2555176.
• Arino J, Woon CW, Brautigan DL, Miller TB, Johnson GL (Jun 1988). "Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes". Proceedings of the National Academy of Sciences of the United States of America 85 (12): 4252–6. doi:10.1073/pnas.85.12.4252. PMC 280405. PMID 2837763.
• Hemmings BA, Wernet W, Mayer R, Maurer F, Hofsteenge J, Stone SR (Dec 1988). "The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunit". Nucleic Acids Research 16 (23): 11366. doi:10.1093/nar/16.23.11366. PMC 339017. PMID 2849765.
• Favre B, Zolnierowicz S, Turowski P, Hemmings BA (Jun 1994). "The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo". The Journal of Biological Chemistry 269 (23): 16311–7. PMID 8206937.
• Keranen LM, Dutil EM, Newton AC (Dec 1995). "Protein kinase C is regulated in vivo by three functionally distinct phosphorylations". Current Biology 5 (12): 1394–1403. doi:10.1016/S0960-9822(95)00277-6. PMID 8749392.
• Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R (Jan 1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters 401 (2-3): 197–201. doi:10.1016/S0014-5793(96)01470-6. PMID 9013886.
• Nagase T, Murakami T, Nozaki H, Inoue R, Nishito Y, Tanabe O, Usui H, Takeda M (Jul 1997). "Tissue and subcellular distributions, and characterization of rat brain protein phosphatase 2A containing a 72-kDa delta/B" subunit". Journal of Biochemistry 122 (1): 178–87. doi:10.1093/oxfordjournals.jbchem.a021726. PMID 9276686.
• Ruediger R, Brewis N, Ohst K, Walter G (Nov 1997). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615.
• Hsu W, Zeng L, Costantini F (Feb 1999). "Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain". The Journal of Biological Chemistry 274 (6): 3439–45. doi:10.1074/jbc.274.6.3439. PMID 9920888.
• Ogris E, Du X, Nelson KC, Mak EK, Yu XX, Lane WS, Pallas DC (May 1999). "A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A". The Journal of Biological Chemistry 274 (20): 14382–91. doi:10.1074/jbc.274.20.14382. PMC 3503312. PMID 10318862.
• De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J (Dec 1999). "Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue". Biochemistry 38 (50): 16539–47. doi:10.1021/bi991646a. PMID 10600115.
• Götz J, Probst A, Mistl C, Nitsch RM, Ehler E (May 2000). "Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development". Mechanisms of Development 93 (1-2): 83–93. doi:10.1016/S0925-4773(00)00267-7. PMID 10781942.
• Lüss H, Klein-Wiele O, Bokník P, Herzig S, Knapp J, Linck B, Müller FU, Scheld HH, Schmid C, Schmitz W, Neumann J (Dec 2000). "Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart". Journal of Molecular and Cellular Cardiology 32 (12): 2349–59. doi:10.1006/jmcc.2000.1265. PMID 11113010.