TLX1

T-cell leukemia homeobox 1
Identifiers
Symbols	TLX1 ; HOX11; TCL3
External IDs	OMIM: 186770 MGI: 98769 HomoloGene: 4031 GeneCards: TLX1 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • protein heterodimerization activity Cellular component • nucleus Biological process • transcription from RNA polymerase II promoter • central nervous system development • positive regulation of cell proliferation • neuron differentiation • cell fate commitment • positive regulation of transcription from RNA polymerase II promoter • spleen development • organ formation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3195	21908
Ensembl	ENSG00000107807	ENSMUSG00000025215
UniProt	P31314	Q9QX99
RefSeq (mRNA)	NM_001195517	NM_021901
RefSeq (protein)	NP_001182446	NP_068701
Location (UCSC)	Chr 10: 101.13 – 101.14 Mb	Chr 19: 45.15 – 45.16 Mb
PubMed search

T-cell leukemia homeobox protein 1 is a protein that in humans is encoded by the TLX1 gene, which was initially named HOX11.^{[1][2][3][4][5]}

Interactions

TLX1 has been shown to interact with PPP1CC,^[6] PPP2CB^[6] and PPP2CA.^[6]

References

1. Hatano M, Roberts CW, Minden M, Crist WM, Korsmeyer SJ (Jul 1991). "Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia". Science 253 (5015): 79–82. doi:10.1126/science.1676542. PMID 1676542.
2. McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
3. "Entrez Gene: TLX1 T-cell leukemia homeobox 1".
4. Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH (Oct 1991). "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24". Proceedings of the National Academy of Sciences of the United States of America 88 (20): 8900–4. PMC 52618. PMID 1681546.
5. Dubé ID, Kamel-Reid S, Yuan CC, Lu M, Wu X, Corpus G, Raimondi SC, Crist WM, Carroll AJ, Minowada J (Dec 1991). "A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)". Blood 78 (11): 2996–3003. PMID 1683261.
6. Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature 385 (6615): 454–8. doi:10.1038/385454a0. PMID 9009195.

Further reading

• Allen TD, Zhu YX, Hawley TS, Hawley RG (Oct 2000). "TALE homeoproteins as HOX11-interacting partners in T-cell leukemia". Leukemia & Lymphoma 39 (3-4): 241–56. doi:10.3109/10428190009065824. PMID 11342305.
• Lu M, Zhang N, Ho AD (Jul 1992). "Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells". Oncogene 7 (7): 1325–30. PMID 1352396.
• Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH (Oct 1991). "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24". Proceedings of the National Academy of Sciences of the United States of America 88 (20): 8900–4. doi:10.1073/pnas.88.20.8900. PMC 52618. PMID 1681546.
• Lu M, Gong ZY, Shen WF, Ho AD (Oct 1991). "The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein". The EMBO Journal 10 (10): 2905–10. PMC 453003. PMID 1717256.
• Dear TN, Colledge WH, Carlton MB, Lavenir I, Larson T, Smith AJ, Warren AJ, Evans MJ, Sofroniew MV, Rabbitts TH (Sep 1995). "The Hox11 gene is essential for cell survival during spleen development". Development 121 (9): 2909–15. PMID 7555717.
• Dear TN, Sanchez-Garcia I, Rabbitts TH (May 1993). "The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes". Proceedings of the National Academy of Sciences of the United States of America 90 (10): 4431–5. doi:10.1073/pnas.90.10.4431. PMC 46525. PMID 8099440.
• Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature 385 (6615): 454–8. doi:10.1038/385454a0. PMID 9009195.
• Brake RL, Kees UR, Watt PM (Oct 1998). "Multiple negative elements contribute to repression of the HOX11 proto-oncogene". Oncogene 17 (14): 1787–95. doi:10.1038/sj.onc.1202078. PMID 9778044.
• Zhang N, Shen W, Hawley RG, Lu M (Apr 1999). "HOX11 interacts with CTF1 and mediates hematopoietic precursor cell immortalization". Oncogene 18 (13): 2273–9. doi:10.1038/sj.onc.1202545. PMID 10327073.
• Watt PM, Ranford PR, Kees UR (Jun 1999). "Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line". Gene 234 (1): 169–76. doi:10.1016/S0378-1119(99)00157-2. PMID 10393251.
• Brake RL, Kees UR, Watt PM (May 2002). "A complex containing PBX2 contributes to activation of the proto-oncogene HOX11". Biochemical and Biophysical Research Communications 294 (1): 23–34. doi:10.1016/S0006-291X(02)00426-6. PMID 12054735.
• Bodenmiller DM, Baxter CS, Hansen DV, Potter SS (Apr 2002). "Phylogenetic analysis of Hoxa 11 sequences reveals absence of transposable elements, conservation of transcription factor binding sites, and suggests antisense coding function". DNA Sequence 13 (2): 77–83. doi:10.1080/10425170290029981. PMID 12180349.
• Cavé H, Suciu S, Preudhomme C, Poppe B, Robert A, Uyttebroeck A, Malet M, Boutard P, Benoit Y, Mauvieux L, Lutz P, Méchinaud F, Grardel N, Mazingue F, Dupont M, Margueritte G, Pages MP, Bertrand Y, Plouvier E, Brunie G, Bastard C, Plantaz D, Vande Velde I, Hagemeijer A, Speleman F, Lessard M, Otten J, Vilmer E, Dastugue N (Jan 2004). "Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951". Blood 103 (2): 442–50. doi:10.1182/blood-2003-05-1495. PMID 14504110.
• Hoffmann K, Dixon DN, Greene WK, Ford J, Taplin R, Kees UR (Dec 2004). "A microarray model system identifies potential new target genes of the proto-oncogene HOX11". Genes, Chromosomes & Cancer 41 (4): 309–20. doi:10.1002/gcc.20104. PMID 15384172.
• Riz I, Hawley RG (Aug 2005). "G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemia". Oncogene 24 (36): 5561–75. doi:10.1038/sj.onc.1208727. PMC 2408753. PMID 15897879.
• Heidari M, Rice KL, Phillips JK, Kees UR, Greene WK (Feb 2006). "The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells". Leukemia 20 (2): 304–12. doi:10.1038/sj.leu.2404071. PMID 16357834.
• Chen E, Lim MS, Rosic-Kablar S, Liu J, Jolicoeur P, Dubé ID, Hough MR (Apr 2006). "Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice". Oncogene 25 (18): 2575–87. doi:10.1038/sj.onc.1209285. PMID 16407851.