PPRC1

Peroxisome proliferator-activated receptor gamma, coactivator-related 1
Identifiers
Symbols	PPRC1 ; PRC
External IDs	MGI: 2385096 HomoloGene: 9006 GeneCards: PPRC1 Gene
Gene ontology Molecular function • nucleotide binding • RNA polymerase II transcription cofactor activity • transcription factor binding • ligand-dependent nuclear receptor transcription coactivator activity • poly(A) RNA binding Cellular component • nucleus • nucleoplasm Biological process • transcription, DNA-templated • organelle organization • mitochondrion organization • positive regulation of transcription from RNA polymerase II promoter • positive regulation of sequence-specific DNA binding transcription factor activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23082	226169
Ensembl	ENSG00000148840	ENSMUSG00000055491
UniProt	Q5VV67	Q6NZN1
RefSeq (mRNA)	NM_001288727	NM_001081214
RefSeq (protein)	NP_001275656	NP_001074683
Location (UCSC)	Chr 10: 102.13 – 102.15 Mb	Chr 19: 46.04 – 46.07 Mb
PubMed search

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 is a protein that in humans is encoded by the PPRC1 gene.^[1][2][3]

The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPARGC1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals.^[3]

Interactions

PPRC1 has been shown to interact with USF2.^[4]

References

1. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
2. Andersson U, Scarpulla RC (May 2001). "PGC-1-Related Coactivator, a Novel, Serum-Inducible Coactivator of Nuclear Respiratory Factor 1-Dependent Transcription in Mammalian Cells". Mol Cell Biol 21 (11): 3738–49. doi:10.1128/MCB.21.11.3738-3749.2001. PMC 87014. PMID 11340167.
3. "Entrez Gene: PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1".
4. Moore, Meredith L; Park Edwards A; McMillin Jeanie B (May 2003). "Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1". J. Biol. Chem. (United States) 278 (19): 17263–8. doi:10.1074/jbc.M210486200. ISSN 0021-9258. PMID 12611894.

Further reading

• Finck BN, Kelly DP (2006). "PGC-1 coactivators: inducible regulators of energy metabolism in health and disease". J. Clin. Invest. 116 (3): 615–22. doi:10.1172/JCI27794. PMC 1386111. PMID 16511594.
• Yamagata K, Yoshimochi K, Daitoku H, et al. (2007). "Bile acid represses the peroxisome proliferator-activated receptor-gamma coactivator-1 promoter activity in a small heterodimer partner-dependent manner". Int. J. Mol. Med. 19 (5): 751–6. doi:10.3892/ijmm.19.5.751. PMID 17390079.
• Srivastava S, Barrett JN, Moraes CT (2007). "PGC-1α/β upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations". Hum. Mol. Genet. 16 (8): 993–1005. doi:10.1093/hmg/ddm045. PMC 2652746. PMID 17341490.
• Gleyzer N, Vercauteren K, Scarpulla RC (2005). "Control of Mitochondrial Transcription Specificity Factors (TFB1M and TFB2M) by Nuclear Respiratory Factors (NRF-1 and NRF-2) and PGC-1 Family Coactivators". Mol. Cell. Biol. 25 (4): 1354–66. doi:10.1128/MCB.25.4.1354-1366.2005. PMC 548005. PMID 15684387.
• Yamamoto T, Shimano H, Nakagawa Y, et al. (2004). "SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes". J. Biol. Chem. 279 (13): 12027–35. doi:10.1074/jbc.M310333200. PMID 14722127.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Savagner F, Mirebeau D, Jacques C, et al. (2003). "PGC-1-related coactivator and targets are upregulated in thyroid oncocytoma". Biochem. Biophys. Res. Commun. 310 (3): 779–84. doi:10.1016/j.bbrc.2003.09.076. PMID 14550271.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scarpulla RC (2002). "Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells". Gene 286 (1): 81–9. doi:10.1016/S0378-1119(01)00809-5. PMID 11943463.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.