USF2

Upstream transcription factor 2, c-fos interacting
Identifiers
Symbols USF2 ; FIP; bHLHb12
External IDs OMIM: 600390 MGI: 99961 HomoloGene: 2527 GeneCards: USF2 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 7392 22282
Ensembl ENSG00000105698 ENSMUSG00000058239
UniProt Q15853 Q64705
RefSeq (mRNA) NM_003367 NM_011680
RefSeq (protein) NP_003358 NP_035810
Location (UCSC) Chr 19:
35.27 – 35.28 Mb		 Chr 7:
30.95 – 30.96 Mb
PubMed search

Upstream stimulatory factor 2 is a protein that in humans just encoded by the USF2 gene.[1][2]

Function

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene.[2]

Interactions

USF2 has been shown to interact with USF1 (human gene),[3][4] PPRC1[5] and BRCA1.[6]

Regulation

The USF2 gene is repressed by the microRNA miR-10a.[7]

References

  1. ↑ Groenen PM, Garcia E, Debeer P, Devriendt K, Fryns JP, Van de Ven WJ (Dec 1996). "Structure, sequence, and chromosome 19 localization of human USF2 and its rearrangement in a patient with multicystic renal dysplasia". Genomics 38 (2): 141–8. doi:10.1006/geno.1996.0609. PMID 8954795.
  2. 1 2 "Entrez Gene: USF2 upstream transcription factor 2, c-fos interacting".
  3. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  4. ↑ Viollet B, Lefrançois-Martinez AM, Henrion A, Kahn A, Raymondjean M, Martinez A (Jan 1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". The Journal of Biological Chemistry 271 (3): 1405–15. doi:10.1074/jbc.271.3.1405. PMID 8576131.
  5. ↑ Moore ML, Park EA, McMillin JB (May 2003). "Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1". The Journal of Biological Chemistry 278 (19): 17263–8. doi:10.1074/jbc.M210486200. PMID 12611894.
  6. ↑ Cable PL, Wilson CA, Calzone FJ, Rauscher FJ, Scully R, Livingston DM, Li L, Blackwell CB, Futreal PA, Afshari CA (Oct 2003). "Novel consensus DNA-binding sequence for BRCA1 protein complexes". Molecular Carcinogenesis 38 (2): 85–96. doi:10.1002/mc.10148. PMID 14502648.
  7. ↑ Agirre X, Jiménez-Velasco A, San José-Enériz E, Garate L, Bandrés E, Cordeu L, Aparicio O, Saez B, Navarro G, Vilas-Zornoza A, Pérez-Roger I, García-Foncillas J, Torres A, Heiniger A, Calasanz MJ, Fortes P, Román-Gómez J, Prósper F (Dec 2008). "Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth". Molecular Cancer Research 6 (12): 1830–40. doi:10.1158/1541-7786.MCR-08-0167. PMID 19074828.

Further reading

  • Corre S, Galibert MD (Jan 2006). "[USF as a key regulatory element of gene expression]". Médecine Sciences 22 (1): 62–7. doi:10.1051/medsci/200622162. PMID 16386222. 
  • Sirito M, Walker S, Lin Q, Kozlowski MT, Klein WH, Sawadogo M (1993). "Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers". Gene Expression 2 (3): 231–40. PMID 1450663. 
  • Blanar MA, Rutter WJ (May 1992). "Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos". Science 256 (5059): 1014–8. doi:10.1126/science.1589769. PMID 1589769. 
  • Viollet B, Lefrançois-Martinez AM, Henrion A, Kahn A, Raymondjean M, Martinez A (Jan 1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". The Journal of Biological Chemistry 271 (3): 1405–15. doi:10.1074/jbc.271.3.1405. PMID 8576131. 
  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Ghosh AK, Datta PK, Jacob ST (Feb 1997). "The dual role of helix-loop--helix-zipper protein USF in ribosomal RNA gene transcription in vivo". Oncogene 14 (5): 589–94. doi:10.1038/sj.onc.1200866. PMID 9053857. 
  • Kurschner C, Morgan JI (Feb 1997). "USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and inhibits c-Maf DNA binding activity". Biochemical and Biophysical Research Communications 231 (2): 333–9. doi:10.1006/bbrc.1997.6097. PMID 9070273. 
  • Breen GA, Jordan EM (Apr 1997). "Regulation of the nuclear gene that encodes the alpha-subunit of the mitochondrial F0F1-ATP synthase complex. Activation by upstream stimulatory factor 2". The Journal of Biological Chemistry 272 (16): 10538–42. doi:10.1074/jbc.272.16.10538. PMID 9099698. 
  • Nechushtan H, Zhang Z, Razin E (Apr 1997). "Microphthalmia (mi) in murine mast cells: regulation of its stimuli-mediated expression on the translational level". Blood 89 (8): 2999–3008. PMID 9108421. 
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. 
  • Breen GA, Jordan EM (Aug 1999). "Transcriptional activation of the F(1)F(0) ATP synthase alpha-subunit initiator element by USF2 is mediated by p300". Biochimica Et Biophysica Acta 1428 (2-3): 169–76. doi:10.1016/s0304-4165(99)00061-6. PMID 10434034. 
  • Kumari D, Usdin K (Feb 2001). "Interaction of the transcription factors USF1, USF2, and alpha -Pal/Nrf-1 with the FMR1 promoter. Implications for Fragile X mental retardation syndrome". The Journal of Biological Chemistry 276 (6): 4357–64. doi:10.1074/jbc.M009629200. PMID 11058604. 
  • Kolonics A, Apáti A, Nahajevszky S, Gáti R, Brózik A, Magócsi M (2002). "Unregulated activation of STAT-5, ERK1/2 and c-Fos may contribute to the phenotypic transformation from myelodysplastic syndrome to acute leukaemia". Haematologia 31 (2): 125–38. doi:10.1163/15685590152492936. PMID 11583024. 
  • Bengtsson SH, Madeyski-Bengtson K, Nilsson J, Bjursell G (Jul 2002). "Transcriptional regulation of the human carboxyl ester lipase gene in THP-1 monocytes: an E-box required for activation binds upstream stimulatory factors 1 and 2". The Biochemical Journal 365 (Pt 2): 481–8. doi:10.1042/BJ20020223. PMC 1222691. PMID 11945176. 
  • Villavicencio EH, Yoon JW, Frank DJ, Füchtbauer EM, Walterhouse DO, Iannaccone PM (Apr 2002). "Cooperative E-box regulation of human GLI1 by TWIST and USF". Genesis 32 (4): 247–58. doi:10.1002/gene.10078. PMID 11948912. 
  • Moore ML, Park EA, McMillin JB (May 2003). "Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1". The Journal of Biological Chemistry 278 (19): 17263–8. doi:10.1074/jbc.M210486200. PMID 12611894. 
  • Pickwell GV, Shih H, Quattrochi LC (Apr 2003). "Interaction of upstream stimulatory factor proteins with an E-box located within the human CYP1A2 5'-flanking gene contributes to basal transcriptional gene activation". Biochemical Pharmacology 65 (7): 1087–96. doi:10.1016/S0006-2952(03)00037-6. PMID 12663044. 
  • Zhu J, Giannola DM, Zhang Y, Rivera AJ, Emerson SG (Oct 2003). "NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4". Blood 102 (7): 2420–7. doi:10.1182/blood-2003-01-0251. PMID 12791656. 

External links

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