PRPF40A

PRP40 pre-mRNA processing factor 40 homolog A
PDB rendering based on 1uzc.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1UZC​, 1YWI​, 1YWJ​, 1ZR7​, 2CQN​, 2DYF​, 2KZG​, 2L5F​, 2L9V​, 2LKS​
Identifiers
Symbols	PRPF40A ; FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10; HYPA; NY-REN-6; Prp40
External IDs	OMIM: 612941 MGI: 1860512 HomoloGene: 6377 GeneCards: PRPF40A Gene
Gene ontology Molecular function • protein binding • poly(A) RNA binding • proline-rich region binding Cellular component • nucleoplasm • cytoplasm • membrane • nuclear matrix • nuclear speck Biological process • mRNA processing • cytoskeleton organization • cell cycle • regulation of cell shape • RNA splicing • cell migration • regulation of cytokinesis • cell division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55660	56194
Ensembl	ENSG00000196504	ENSMUSG00000061136
UniProt	O75400	Q9R1C7
RefSeq (mRNA)	NM_017892	NM_018785
RefSeq (protein)	NP_060362	NP_061255
Location (UCSC)	Chr 2: 152.65 – 152.72 Mb	Chr 2: 53.13 – 53.19 Mb
PubMed search

Pre-mRNA-processing factor 40 homolog A is a protein that in humans is encoded by the PRPF40A gene.^[1][2][3]

Interactions

PRPF40A has been shown to interact with Huntingtin.^[4]

References

1. Bedford MT, Reed R, Leder P (Sep 1998). "WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif". Proc Natl Acad Sci U S A 95 (18): 10602–7. doi:10.1073/pnas.95.18.10602. PMC 27941. PMID 9724750.
2. Wiesner S, Stier G, Sattler M, Macias MJ (Dec 2002). "Solution structure and ligand recognition of the WW domain pair of the yeast splicing factor Prp40". J Mol Biol 324 (4): 807–22. doi:10.1016/S0022-2836(02)01145-2. PMID 12460579.
3. "Entrez Gene: PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)".
4. Faber, P W; Barnes G T; Srinidhi J; Chen J; Gusella J F; MacDonald M E (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Hum. Mol. Genet. (ENGLAND) 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. ISSN 0964-6906. PMID 9700202.

Further reading

• Chan DC, Bedford MT, Leder P (1996). "Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains.". EMBO J. 15 (5): 1045–54. PMC 450002. PMID 8605874.
• Bedford MT, Chan DC, Leder P (1997). "FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands.". EMBO J. 16 (9): 2376–83. doi:10.1093/emboj/16.9.2376. PMC 1169838. PMID 9171351.
• Faber PW, Barnes GT, Srinidhi J, et al. (1998). "Huntingtin interacts with a family of WW domain proteins.". Hum. Mol. Genet. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
• Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma.". Int. J. Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
• Bedford MT, Sarbassova D, Xu J, et al. (2000). "A novel pro-Arg motif recognized by WW domains.". J. Biol. Chem. 275 (14): 10359–69. doi:10.1074/jbc.275.14.10359. PMID 10744724.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Wenzel J, Sanzenbacher R, Ghadimi M, et al. (2002). "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor.". FEBS Lett. 509 (2): 255–62. doi:10.1016/S0014-5793(01)03174-X. PMID 11741599.
• Allen M, Friedler A, Schon O, Bycroft M (2002). "The structure of an FF domain from human HYPA/FBP11.". J. Mol. Biol. 323 (3): 411–6. doi:10.1016/S0022-2836(02)00968-3. PMID 12381297.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Katoh M, Katoh M (2004). "Identification and characterization of human FNBP3 gene in silico.". Int. J. Mol. Med. 12 (4): 651–6. doi:10.3892/ijmm.12.4.651. PMID 12964049.
• Busino L, Donzelli M, Chiesa M, et al. (2003). "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.". Nature 426 (6962): 87–91. doi:10.1038/nature02082. PMID 14603323.
• Mizutani K, Suetsugu S, Takenawa T (2004). "FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation.". Biochem. Biophys. Res. Commun. 313 (3): 468–74. doi:10.1016/j.bbrc.2003.11.139. PMID 14697212.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.". Mol. Cell 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
• Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo.". Mol. Cell. Biol. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMC 517884. PMID 15456888.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.