PUM1

Pumilio RNA-binding family member 1
PDB rendering based on 1ib2.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1IB2​, 1M8W​, 1M8X​, 1M8Y​, 1M8Z​, 2YJY​, 3BSB​, 3BSX​, 3Q0L​, 3Q0M​, 3Q0N​, 3Q0O​, 3Q0P​
Identifiers
Symbols	PUM1 ; HSPUM; PUMH; PUMH1; PUML1
External IDs	OMIM: 607204 MGI: 1931749 HomoloGene: 22830 GeneCards: PUM1 Gene
Gene ontology Molecular function • mRNA 3'-UTR binding • protein binding • poly(A) RNA binding Cellular component • cytoplasmic mRNA processing body • cytosol • cytoplasmic stress granule Biological process • post-Golgi vesicle-mediated transport • spermatogenesis • adult locomotory behavior • posttranscriptional gene silencing • stem cell differentiation • regulation of cell cycle • regulation of gene silencing by miRNA • membrane organization • mRNA destabilization • positive regulation of RIG-I signaling pathway • positive regulation of gene silencing by miRNA Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9698	80912
Ensembl	ENSG00000134644	ENSMUSG00000028580
UniProt	Q14671	Q80U78
RefSeq (mRNA)	NM_001020658	NM_001159603
RefSeq (protein)	NP_001018494	NP_001153075
Location (UCSC)	Chr 1: 30.93 – 31.07 Mb	Chr 4: 130.66 – 130.78 Mb
PubMed search

Pumilio homolog 1 is a protein that in humans is encoded by the PUM1 gene.^[1]

Function

This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain composed of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described.^[1]

References

1. "Entrez Gene: PUM1 pumilio homolog 1 (Drosophila)".

Further reading

• Spassov DS, Jurecic R (2004). "The PUF family of RNA-binding proteins: does evolutionarily conserved structure equal conserved function?". IUBMB Life 55 (7): 359–66. doi:10.1080/15216540310001603093. PMID 14584586.
• Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wang X, Zamore PD, Hall TM (2001). "Crystal structure of a Pumilio homology domain". Mol. Cell 7 (4): 855–65. doi:10.1016/S1097-2765(01)00229-5. PMID 11336708.
• Wang X, McLachlan J, Zamore PD, Hall TM (2002). "Modular recognition of RNA by a human pumilio-homology domain". Cell 110 (4): 501–12. doi:10.1016/S0092-8674(02)00873-5. PMID 12202039.
• Spassov DS, Jurecic R (2003). "Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins". Gene 299 (1–2): 195–204. doi:10.1016/S0378-1119(02)01060-0. PMID 12459267.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dazard JE, Gal H, Amariglio N, et al. (2003). "Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer". Oncogene 22 (19): 2993–3006. doi:10.1038/sj.onc.1206537. PMID 12771951.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Jordanova A, Irobi J, Thomas FP, et al. (2006). "Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy". Nat. Genet. 38 (2): 197–202. doi:10.1038/ng1727. PMID 16429158.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.