Paul L. Modrich
| Paul L. Modrich | |
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Paul L. Modrich, Nobel Laureate in chemistry in Stockholm December 2015 | |
| Born |
Paul Lawrence Modrich June 13, 1946 Raton, New Mexico, U.S. |
| Nationality | United States |
| Fields | DNA mismatch repair |
| Institutions | |
| Alma mater | MIT, Stanford University (PhD) |
| Known for | Clarification of cellular resistance to carcinogens |
| Notable awards |
Nobel Prize in Chemistry (2015)
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Website Paul L. Modrich | |
Paul Lawrence Modrich (born June 13, 1946) is an American biochemist, James B. Duke Professor of Biochemistry at Duke University and Investigator at the Howard Hughes Medical Institute. He received a Ph.D. degree in 1973 from Stanford University and an B.S. degree in 1968 from MIT. He is known for his research on DNA mismatch repair.[1] Modrich received the Nobel Prize in Chemistry 2015, jointly with Aziz Sancar and Tomas Lindahl.[2][3]
Early life
Modrich was born on June 13, 1946, in Raton, New Mexico. He is of Croatian descent; his paternal grandfather and grandmother (of Montenegrin descent) immigrated to the United States from Croatia.[4]
Research
Modrich joined Duke University's faculty in 1976 and has been a Howard Hughes Investigator since 1995. He works primarily on strand-directed mismatch repair. His lab demonstrated how DNA mismatch repair serves as a copyeditor to prevent errors from DNA polymerase. Matthew Meselson previously proposed the existence of recognition of mismatches. Modrich performed biochemical experiments to study mismatch repair in E. coli.[5] They later searched for proteins associated with mismatch repair in humans.[1]
Dr. Modrich is also a fellow of the American Academy of Arts and Sciences, and a member of the Institute of Medicine and the National Academy of Sciences.
References
- 1 2 "Paul Modrich Awarded 2015 Nobel Prize in Chemistry". HHMI. HHMI. October 7, 2015. Retrieved December 13, 2015.
- ↑ Broad, William J. (October 7, 2015). "Nobel Prize in Chemistry Awarded to Tomas Lindahl, Paul Modrich and Aziz Sancar for DNA Studies". The New York Times. ISSN 0362-4331. Retrieved December 13, 2015.
- ↑ Staff (October 7, 2015). "THE NOBEL PRIZE IN CHEMISTRY 2015 - DNA repair – providing chemical stability for life" (PDF). Nobel Prize. Retrieved December 13, 2015.
- ↑ Nenad Jarić Dauenhauer (October 26, 2015). "Nobelovac Modrich za tportal: Djed mi je bio Hrvat" [Nobel laureate Modrich for tportal: My grandfather was a Croat]. tportal.hr (T-Hrvatski Telekom). Retrieved December 13, 2015.
- ↑ Su, SS; Modrich, P (July 1986). "Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs.". Proceedings of the National Academy of Sciences of the United States of America 83 (14): 5057–61. doi:10.1073/pnas.83.14.5057. PMID 3014530.
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