Penitrem A
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| Names | |
|---|---|
| Other names
Tremortin | |
| Identifiers | |
12627-35-9  | |
| ChemSpider | 298950  |
| Jmol interactive 3D | Image |
| PubChem | 337313 |
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| |
| Properties | |
| C37H44ClNO6 | |
| Molar mass | 634.20136 |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| verify (what is ?) | |
| Infobox references | |
Penitrem A (tremortin) is a fungal neurotoxin found on ryegrass. It is produced by certain species of Aspergillus, Claviceps, and Penicillium. It inhibits potassium channels in smooth muscles. The maxi-channels targeted have their highest density in the cerebellar Purkinje cells.
It causes a stagger in horses and cattle.
Effective dose
The ED50 for penitrem A is 10 nM. The ED50 is the effective dose for 50% of the population. Many toxic chemicals do not show ED-50s and act by irreversible covalent adduction.
Stages of toxicity
See also
References
- Walter SL (2002). "Acute penitrem A and roquefortine poisoning in a dog". Can. Vet. J. 43 (5): 372–4. PMC 339273. PMID 12001505.
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