Peptide-methionine (S)-S-oxide reductase

Peptide-methionine (S)-S-oxide reductase
Identifiers
EC number 1.8.4.11
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Peptide-methionine (S)-S-oxide reductase (EC 1.8.4.11, MsrA, methionine sulphoxide reductase A, methionine S-oxide reductase (S-form oxidizing), methionine sulfoxide reductase A, peptide methionine sulfoxide reductase) is an enzyme with systematic name peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase (L-methionine (S)-S-oxide-forming).[1][2][3][4][5][6][7][8][9][10] This enzyme catalyses the following chemical reaction

(1) peptide-L-methionine + thioredoxin disulfide + H2O \rightleftharpoons peptide-L-methionine (S)-S-oxide + thioredoxin
(2) L-methionine + thioredoxin disulfide + H2O \rightleftharpoons L-methionine (S)-S-oxide + thioredoxin

The reaction occurs in the reverse direction.

References

  1. ↑ Moskovitz, J., Singh, V.K., Requena, J., Wilkinson, B.J., Jayaswal, R.K. and Stadtman, E.R. (2002). "Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity". Biochem. Biophys. Res. Commun. 290: 62–65. doi:10.1006/bbrc.2001.6171. PMID 11779133.
  2. ↑ Taylor, A.B., Benglis, D.M., Jr., Dhandayuthapani, S. and Hart, P.J. (2003). "Structure of Mycobacterium tuberculosis methionine sulfoxide reductase A in complex with protein-bound methionine". J. Bacteriol. 185: 4119–4126. doi:10.1128/JB.185.14.4119-4126.2003. PMC 164888. PMID 12837786.
  3. ↑ Singh, V.K. and Moskovitz, J. (2003). "Multiple methionine sulfoxide reductase genes in Staphylococcus aureus: expression of activity and roles in tolerance of oxidative stress". Microbiology 149: 2739–2747. doi:10.1099/mic.0.26442-0. PMID 14523107.
  4. ↑ Boschi-Muller, S., Olry, A., Antoine, M. and Branlant, G. (2005). "The enzymology and biochemistry of methionine sulfoxide reductases". Biochim. Biophys. Acta 1703: 231–238. doi:10.1016/j.bbapap.2004.09.016. PMID 15680231.
  5. ↑ Ezraty, B., Aussel, L. and Barras, F. (2005). "Methionine sulfoxide reductases in prokaryotes". Biochim. Biophys. Acta 1703: 221–229. doi:10.1016/j.bbapap.2004.08.017. PMID 15680230.
  6. ↑ Weissbach, H., Resnick, L. and Brot, N. (2005). "Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage". Biochim. Biophys. Acta 1703: 203–212. doi:10.1016/j.bbapap.2004.10.004. PMID 15680228.
  7. ↑ Kauffmann, B., Aubry, A. and Favier, F. (2005). "The three-dimensional structures of peptide methionine sulfoxide reductases: current knowledge and open questions". Biochim. Biophys. Acta 1703: 249–260. doi:10.1016/j.bbapap.2004.09.008. PMID 15680233.
  8. ↑ Vougier, S., Mary, J. and Friguet, B. (2003). "Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells". Biochem. J. 373: 531–537. doi:10.1042/BJ20030443. PMC 1223498. PMID 12693988.
  9. ↑ Olry, A., Boschi-Muller, S., Marraud, M., Sanglier-Cianferani, S., Van Dorsselear, A. and Branlant, G. (2002). "Characterization of the methionine sulfoxide reductase activities of PILB, a probable virulence factor from Neisseria meningitidis". J. Biol. Chem. 277: 12016–12022. doi:10.1074/jbc.M112350200. PMID 11812798.
  10. ↑ Brot, N., Weissbach, L., Werth, J. and Weissbach, H. (1981). "Enzymatic reduction of protein-bound methionine sulfoxide". Proc. Natl. Acad. Sci. USA 78 (4): 2155–2158. doi:10.1073/pnas.78.4.2155. PMC 319302. PMID 7017726.

External links

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