Peter Duesberg

Peter H. Duesberg
Born (1936-12-02) December 2, 1936
Münster, Germany
Residence Oakland, California
Fields Cancer
Institutions University of California, Berkeley
Alma mater University of Frankfurt
Thesis Fraktionierungen von Proteinen – besonders Enzymen – mit Ionenaustauschern und Molekularsieben <vom Typ Sephadex> (1963)
Known for Oncogene research; AIDS denialism

Peter H. Duesberg (born December 2, 1936) is a German American molecular biologist and a professor of molecular and cell biology at the University of California, Berkeley. He is known for his early research into genetic aspects of cancer, and more recently for his central role in the AIDS denialism movement as a proponent of the belief that HIV is harmless and does not cause AIDS. Duesberg received acclaim early in his career for research on oncogenes and cancer. With Peter K. Vogt, he reported in 1970 that a cancer-causing virus of birds had extra genetic material compared with non-cancer-causing viruses, hypothesizing that this material contributed to cancer.[1][2] At the age of 36, Duesberg was awarded tenure at the University of California, Berkeley, and at 49 he was elected to the National Academy of Sciences. He received an Outstanding Investigator Grant (OIG) from the National Institutes of Health (NIH) in 1986, and from 1986 to 1987 was a Fogarty Scholar-in-Residence at the NIH laboratories in Bethesda, Maryland.

Long considered a contrarian by his scientific colleagues,[3] Duesberg began to gain public notoriety with a March 1987 article in Cancer Research entitled "Retroviruses as Carcinogens and Pathogens: Expectations and Reality".[4] In this and subsequent writings, Duesberg proposed his hypothesis that AIDS is caused by long-term consumption of recreational drugs or antiretroviral drugs, and that HIV is a harmless passenger virus. In contrast, the scientific consensus is that HIV infection causes AIDS;[5] Duesberg's HIV/AIDS claims have been addressed and rejected as erroneous by the scientific community.[6][7][8] Reviews of his opinions in Nature[9] and Science[10] asserted that they were unpersuasive and based on selective reading of the literature, and that although Duesberg had a right to a dissenting opinion, his failure to fairly review evidence that HIV causes AIDS meant that his opinion lacked credibility.[10][11]

Duesberg's views are cited as major influences on South African HIV/AIDS policy under the administration of Thabo Mbeki, which embraced AIDS denialism. Duesberg served on an advisory panel to Mbeki, convened in 2000. The Mbeki administration's failure to provide antiretroviral drugs in a timely manner, due in part to the influence of AIDS denialism, is thought to be responsible for hundreds of thousands of preventable AIDS deaths and HIV infections in South Africa.[12][13] Duesberg disputed these findings in an article in the journal Medical Hypotheses,[14] but the journal's publisher, Elsevier, later retracted Duesberg's article over accuracy and ethics concerns as well as its rejection during peer review.[15][16] The incident prompted several complaints to Duesberg's institution, the University of California, Berkeley, which began a misconduct investigation of Duesberg in 2009.[17][18] The investigation was dropped in 2010, with University officials finding "insufficient evidence...to support a recommendation for disciplinary action."[19][20]

Work

Cancer

Duesberg grew up during World War II, raised as a Catholic in Germany.[21] He moved to Berkeley, California, in 1964 to work at the University of California, Berkeley, following completion of a PhD in chemistry at the University of Frankfurt.[21] In the 1970s Duesberg won international acclaim for his groundbreaking work on cancer.[22] Duesberg's early work on cancer included being the first to identify the oncogene v-src from the genome of Rous sarcoma virus, a chicken virus believed to trigger tumor growth.[21]

Duesberg disputes the importance of oncogenes and retroviruses in cancer. He supports the aneuploidy hypothesis of cancer that was first proposed in 1914 by Theodor Heinrich Boveri.[21][23]

Duesberg rejects the importance of mutations, oncogenes, and anti-oncogenes entirely. Duesberg along with other researchers, in a 1998 paper published in Proceedings of the National Academy of Sciences, reported a mathematical correlation between chromosome number and the genetic instability of cancer cells, which they dubbed "the ploidy factor,"[24] confirming earlier research by other groups[25] that demonstrated an association between degree of aneuploidy and metastasis. Although unwilling to concur with Duesberg in throwing out a role for cancer genes, many researchers do support exploration of alternative hypotheses.[26] Research and debate on this subject is ongoing. In 2007, Scientific American published an article by Duesberg on his aneuploidy cancer theory.[27] In an editorial explaining their decision to publish this article, the editors of Scientific American stated: "Thus, as wrong as Duesberg surely is about HIV, there is at least a chance that he is significantly right about cancer."[28]

AIDS

Main article: Duesberg hypothesis

In his 1996 book Inventing the AIDS Virus and in numerous journal articles and letters to the editor, Duesberg asserts that HIV is harmless and that recreational and pharmaceutical drug use, especially of zidovudine (AZT, a drug used in the treatment of AIDS) are the causes of AIDS outside Africa (the so-called Duesberg hypothesis). He considers AIDS diseases as markers for drug use, e.g. use of poppers (alkyl nitrites) among some homosexuals, asserting a correlation between AIDS and recreational drug use.[29] This correlation hypothesis has been disproven by evidence showing that only HIV infection, not homosexuality nor recreational/pharmaceutical drug use, predicts who will develop AIDS.[5][7][30][31][32]

Duesberg asserts that AIDS in Africa is misdiagnosed and the epidemic a "myth", claiming incorrectly[33] that the diagnostic criteria for AIDS are different in Africa than elsewhere[34][35] and that the breakdown of the immune system in African AIDS patients can be explained exclusively by factors such as malnutrition, tainted drinking water, and various infections that he presumes are common to AIDS patients in Africa.[35] Duesberg also argues that retroviruses like HIV must be harmless to survive, and that the normal mode of retroviral propagation is mother-to-child transmission by infection in utero.[36]

Since Duesberg published his first paper on the subject in 1987, scientists have examined and criticized the accuracy of his hypotheses on AIDS causation. Duesberg sustained a long dispute with John Maddox, then-editor of the scientific journal Nature, demanding the right to rebut articles that HIV caused AIDS. For several years Maddox consented to this demand[9] but ultimately refused to continue to publish Duesberg's criticisms:

[Duesberg] forfeited the right to expect answers by his rhetorical technique. Questions left unanswered for more than about ten minutes he takes as further proof that HIV is not the cause of AIDS. Evidence that contradicts his alternative drug hypothesis is on the other hand brushed aside...Duesberg will not be alone in protesting that this is merely a recipe for suppressing challenges to received wisdom. So it can be. But Nature will not so use it. Instead, what Duesberg continues to say about the causation of AIDS will be reported in the general interest. When he offers a text for publication that can be authenticated, it will if possible be published.
— Maddox, 1993[11]

A number of scientific criticisms of Duesberg's hypothesis were summarized in a review article in the journal Science in 1994, which presented the results of a 3-month scientific investigation into some of Duesberg's claims. In the Science article, science writer Jon Cohen interviewed both HIV researchers and AIDS denialists (including Duesberg himself) and examined the AIDS literature in addition to review articles written by Duesberg. The article stated:

...although the Berkeley virologist raises provocative questions, few researchers find his basic contention that HIV is not the cause of AIDS persuasive. Mainstream AIDS researchers argue that Duesberg's arguments are constructed by selective reading of the scientific literature, dismissing evidence that contradicts his theses, requiring impossibly definitive proof, and dismissing outright studies marked by inconsequential weaknesses.
— Jon Cohen.[10]

The article also stated that although Duesberg and the AIDS denialist movement have garnered support from some prominent scientists, including Nobel Prize winner Kary Mullis, most of this support is related to Duesberg's right to hold a dissenting opinion, rather than support of his specific claim that HIV does not cause AIDS.[10] Duesberg has been described as "the individual who has done the most damage" regarding denialism, due to the apparent scientific legitimacy his scientific credentials give to his statements.[6]

In a 2010 article on conspiracy theories in science, Ted Goertzel highlights Duesberg's opposition to the HIV/AIDS connection as an example in which scientific findings are disputed on irrational grounds, relying on rhetoric, appeal to fairness and the right to a dissenting opinion rather than on evidence. Goertzel stated that Duesberg, along with many other denialists frequently invoke the meme of a "courageous independent scientist resisting orthodoxy", invoking the name of persecuted physicist and astronomer Galileo Galilei.[9] Regarding this comparison, Goertzel stated:

...being a dissenter from orthodoxy is not difficult; the hard part is actually having a better theory. Publishing dissenting theories is important when they are backed by plausible evidence, but this does not mean giving critics 'equal time' to dissent from every finding by a mainstream scientist.
— Goertzel, 2010[9]

Duesberg's advocacy of AIDS denialism has, by all accounts, effectively blackballed him from the worldwide scientific community.[3]

Consequences of AIDS denialism

In 2000, Duesberg was the most prominent AIDS denialist to sit on a 44-member Presidential Advisory Panel on HIV and AIDS convened by then-President Thabo Mbeki of South Africa.[37] The panel was scheduled to meet concurrently with the 2000 International AIDS Conference in Durban and to convey the impression that Mbeki's doubts about HIV/AIDS science were valid and actively discussed in the scientific community.[13] The views of the denialists on the panel, aired during the AIDS conference, received renewed attention.[38] Mbeki later suffered substantial political fallout for his support for AIDS denialism[39][40] and for opposing the treatment of pregnant HIV-positive South African women with antiretroviral medication.[41] Mbeki partly attenuated his ties with denialists in 2002, asking them to stop associating their names with his.[42]

In response to the inclusion of AIDS denialists on Mbeki's panel, the Durban Declaration was drafted and signed by over 5,000 scientists and physicians, describing the evidence that HIV causes AIDS as "clear-cut, exhaustive and unambiguous".[43]

Two independent studies have concluded that the public health policies of Thabo Mbeki's government, shaped in part by Duesberg's writings and advice, were responsible for over 330,000 excess AIDS deaths and many preventable infections, including those of infants.[12][13]

A 2008 feature story on Duesberg in Discover addresses Duesberg's role in anti-HIV drug-preventable deaths in South Africa. Jeanne Linzer interviews prominent HIV/AIDS expert Max Essex, who suggests that,

...history will judge Duesberg as either "a nut who is just a tease to the scientific community" or an "enabler to mass murder" for the deaths of many AIDS patients in Africa.[3]

Academic misconduct investigation

In 2009, Duesberg and co-authors including David Rasnick published an article in the journal Medical Hypotheses, which is not peer reviewed. The article had been rejected previously by the journal JAIDS, and a peer reviewer had warned that the authors could face scientific misconduct charges if the paper were published.

The reviewers claimed that Duesberg and his co-authors cherry-picked data, cited favorable results while ignoring unfavorable results, and quoted statements out of context. Moreover, they claim that Duesberg "[committed] a serious breach of professional ethics" by failing to state a possible conflict of interest: That co-author Rasnick previously worked for Matthias Rath, a vitamin entrepreneur who sold vitamin pills as AIDS remedies. The article was not revised in response to these criticisms.[18]

In the article, Duesberg questioned research reporting that drugs policies implemented by the South African government on the advice of Duesberg, Rasnick and others had led to excess AIDS deaths.[14] Observing that the overall population of South Africa has increased, Duesberg claimed that HIV must be a harmless "passenger virus" that has not caused deaths in South Africa or elsewhere. Duesberg stated that HIV does not replicate in the body and that antiviral drugs, which he calls "inevitably toxic", do not inhibit HIV. In addition, Duesberg wrote that neither he nor his co-authors had financial conflicts of interest.[14]

Scientists expressed concerns to Elsevier, the publisher of Medical Hypotheses, about unsupported assertions and incorrect statements by Duesberg. After an internal review and with a unanimous recommendation of rejection by five Lancet reviewers, Elsevier stated that the article was flawed and of potential danger to global public health.[14] Elsevier permanently withdrew[44] the Duesberg article and another AIDS denialist publication and asked that the editor of the journal implement a peer review process.[15][16][45]

Letters of complaint to the University of California, Berkeley, including one from Nathan Geffen of the South African Treatment Action Campaign (TAC), prompted university officials to open an inquiry into possible academic misconduct related to false statements and failure to disclose potential conflicts of interest.[17][18] The investigation was dropped in 2010, with University officials finding "insufficient evidence...to support a recommendation for disciplinary action." The investigation did not evaluate the merits of the research but found that publishing the article was protected by the principle of academic freedom.[19]

References

  1. ↑ Duesberg P and Vogt P (1970). "Differences between the ribonucleic acids of transforming and nontransforming avian tumor viruses". Proc Natl Acad Sci USA 67 (4): 1673–80. Bibcode:1970PNAS...67.1673D. doi:10.1073/pnas.67.4.1673. PMC 283411. PMID 4321342. 4321342.
  2. ↑ Biography of Peter Duesberg, hosted by the U.S. National Academy of Sciences. Accessed 2010-06-11.
  3. 1 2 3 Linzer, Jeanne (June 15, 2008). "AIDS "Dissident" Seeks Redemption... and a Cure for Cancer". Discover. Retrieved 2008-05-16.
  4. ↑ Duesberg P (March 1, 1987). "Retroviruses as carcinogens and pathogens: expectations and reality". Cancer Res 47 (5): 1199–220. PMID 3028606.
  5. 1 2 "The Evidence That HIV Causes AIDS". National Institute of Allergy and Infectious Disease. Retrieved 2010-04-29.
  6. 1 2 Kalichman, Seth C. (2009). Denying AIDS: Conspiracy Theories, Pseudoscience, and Human Tragedy. Berlin: Springer. pp. 25–56. ISBN 0-387-79475-1.
  7. 1 2 Schechter M, Craib K, Gelmon K, Montaner J, Le T, O'Shaughnessy M (1993). "HIV-1 and the aetiology of AIDS". Lancet 341 (8846): 658–9. doi:10.1016/0140-6736(93)90421-C. PMID 8095571.
  8. ↑ Weiss RA, Jaffe HW (June 1990). "Duesberg, HIV and AIDS" (PDF). Nature 345 (6277): 659–60. Bibcode:1990Natur.345..659W. doi:10.1038/345659a0. PMID 2163025.
  9. 1 2 3 4 Goertzel, T. (2010). "Conspiracy theories in science". EMBO Reports 11 (7): 493–499. doi:10.1038/embor.2010.84. PMC 2897118. PMID 20539311.
  10. 1 2 3 4 Cohen, J. (1994). "The Duesberg phenomenon" (PDF). Science 266 (5191): 1642–1644. Bibcode:1994Sci...266.1642C. doi:10.1126/science.7992043. PMID 7992043. See also The Controversy over HIV and AIDS, the full set of articles by Cohen.
  11. 1 2 Maddox, J. (1993). "Has Duesberg a right of reply?". Nature 363 (6425): 109–199. Bibcode:1993Natur.363..109M. doi:10.1038/363109a0. PMID 8483492.
  12. 1 2 Chigwedere P, Seage GR, Gruskin S, Lee TH, Essex M (October 2008). "Estimating the Lost Benefits of Antiretroviral Drug Use in South Africa". Journal of acquired immune deficiency syndromes (1999) 49 (4): 410–415. doi:10.1097/QAI.0b013e31818a6cd5. PMID 19186354. Lay summary.
  13. 1 2 3 Nattrass N (February 2008). "AIDS and the Scientific Governance of Medicine in Post-Apartheid Africa". African Affairs 107 (427): 157–76. doi:10.1093/afraf/adm087.
  14. 1 2 3 4 Duesberg PH, Nicholson JM, Rasnick D, Fiala C, Bauer HH (July 2009). "WITHDRAWN: HIV-AIDS hypothesis out of touch with South African AIDS – A new perspective". Med Hypotheses. doi:10.1016/j.mehy.2009.06.024. PMID 19619953. Archived from the original on August 11, 2009.
  15. 1 2 Corbyn, Zoë (April 7, 2010). "Editor digs in over Medical Hypotheses reform". Times Higher Education.
  16. 1 2 Goldacre, Ben (September 11, 2009). "Peer review is flawed but the best we've got". The Guardian (UK).
  17. 1 2 Miller, Greg (April 16, 2010). "AIDS Scientist Investigated for Misconduct After Complaint". Science, American Association for the Advancement of Science.
  18. 1 2 3 Cartwright, Jon (May 4, 2010). "AIDS contrarian ignored warnings of scientific misconduct". Nature.
  19. 1 2 "http://news.sciencemag.org/scienceinsider/2010/06/berkeley-drops-probe-of-duesberg.html", Science, June 21, 2010
  20. ↑ "Professor Did Not Violate Campus Policy, Investigation Finds", June 22, 2010
  21. 1 2 3 4 "The World’s Most Reviled Genius", Newsweek, October 9, 2009
  22. ↑ AIDS contrarian ignored warnings of scientific misconduct
  23. ↑ Biozentrum Universitaet Wuerzburg: Theodor Boveri Archived February 24, 2012, at the Wayback Machine.
  24. ↑ Duesberg P, Rausch C, Rasnick D, Hehlmann R (November 1998). "Genetic instability of cancer cells is proportional to their degree of aneuploidy". Proc. Natl. Acad. Sci. U.S.A. 95 (23): 13692–7. Bibcode:1998PNAS...9513692D. doi:10.1073/pnas.95.23.13692. PMC 24881. PMID 9811862.
  25. ↑ Wahlström B, Branehög I, Stierner U, Sunzel H, Holmberg E (April 1992). "Association of ploidy and cell proliferation, Dukes' classification, and histopathological differentiation in adenocarcinomas of colon and rectum". Eur J Surg 158 (4): 237–42; discussion 242–3. PMID 1352139.
  26. ↑ Gibbs WW (July 2003). "Untangling the roots of cancer". Sci. Am. 289 (1): 56–65. doi:10.1038/scientificamerican0703-56. PMID 12840947.
  27. ↑ Duesberg P (May 2007). "Chromosomal chaos and cancer". Sci. Am. 296 (5): 52–9. doi:10.1038/scientificamerican0507-52. PMID 17500414.
  28. ↑ "When pariahs have good ideas". Sci. Am. 296 (5): 10. May 2007. doi:10.1038/scientificamerican0507-10. PMID 17500402.
  29. ↑ Duesberg, 1997, pp. 260-9.
  30. ↑ Vermund S, Hoover D, Chen K (1993). "CD4+ counts in seronegative homosexual men. The Multicenter AIDS Cohort Study". N Engl J Med 328 (6): 442. doi:10.1056/NEJM199302113280615. PMID 8093639.
  31. ↑ Des Jarlais D, Friedman S, Marmor M, Mildvan D, Yancovitz S, Sotheran J, Wenston J, Beatrice S (1993). "CD4 lymphocytopenia among injecting drug users in New York City". J Acquir Immune Defic Syndr 6 (7): 820–2. PMID 8099613.
  32. ↑ Chao C, Jacobson LP, Tashkin D, et al. (2008). "Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men". Drug Alcohol Depend 94 (1–3): 165–71. doi:10.1016/j.drugalcdep.2007.11.010. PMC 2691391. PMID 18180115.
  33. ↑ "AIDS diagnosis information". World Health Organization. Retrieved 2010-10-01.
  34. ↑ Hodgkinson, N (2003). "AIDS: Scientific or Viral Catastrophe?" (PDF). Archived from the original (pdf) on September 27, 2006. Retrieved 2006-10-11.
  35. 1 2 Duesberg P, Koehnlein C, Rasnick D (2003). "The chemical bases of the various AIDS epidemics: recreational drugs, anti-viral chemotherapy and malnutrition". J Biosci 28 (4): 383–412. doi:10.1007/BF02705115. PMID 12799487.
  36. ↑ Duesberg, PH (1996). Inventing the AIDS Virus. Regnery. p. 179. ISBN 0-89526-399-8.
  37. ↑ Sithole, Emelia (July 4, 2000). "S.Africa AIDS panel to validate HIV tests". Reuters. Archived from the original on August 28, 2008. Retrieved 2008-11-24.
  38. ↑ Schoofs, Mark (July 4, 2000). "Debating the Obvious". Village Voice. Retrieved 2008-11-24.
  39. ↑ McGreal, Chris (March 2002). "Thabo Mbeki's catastrophe". Prospect Magazine. Retrieved 2010-10-24.
  40. ↑ tpan.com, "Mbeki fails to break the silence," by Charles E. Clifton, September/October 2000, accessed January 6, 2007,
  41. ↑ Karon, Tony (April 21, 2000). "Why South Africa Questions the Link Between HIV and AIDS". TIME. Retrieved 2007-01-06.
  42. ↑ Journ-AIDS:Factsheet Mbeki Distances Himself from AIDS Dissidents (April 2002). Accessed May 14, 2008.
  43. ↑ , (2000). "The Durban Declaration". Nature 406 (6791): 15–6. doi:10.1038/35017662. PMID 10894520.
  44. ↑ Withdrawal notice
  45. ↑ Martin Enserink, Elsevier to Editor: Change Controversial Journal or Resign. Science, March 8, 2010

Further reading

External links

Mainstream scientific opinion

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