Peter K. Vogt

Peter K. Vogt (March 10, 1932 in Broumov,[1] Czechoslovakia) is an American molecular biologist, virologist and geneticist. His research focuses on retroviruses and viral and cellular oncogenes.

Vogt received his undergraduate education in biology at the University of Würzburg and in 1959 was awarded his Ph.D. at the University of Tübingen for work done at the Max Planck Institute for Virology in Tübingen. From 1959 to 1962 he was Damon Runyon Cancer Research Fellow in the laboratory of Harry Rubin at the University of California in Berkeley and started work on Rous sarcoma virus.[2][3][4] He taught microbiology and molecular biology to medical and graduate students at the University of Colorado in Denver (1962–1967) and the University of Washington in Seattle (1967–1971). In 1971, he joined the University of Southern California as Hastings Professor of Microbiology and in 1980 assumed the chairmanship of the Department of Microbiology at the School of Medicine. Since 1993, he has been a Professor at The Scripps Research Institute in La Jolla.[5][6] He became Executive Vice President and Chief Scientific Officer at Scripps in 2012.[7]

At the beginning of his scientific career, Vogt studied mechanisms of retroviral cell entry and the role of viral surface proteins in determining host range.[8][9][10] He defined related groups of viral surface proteins and their corresponding receptors on the cell surface.[11][12] During his time in Seattle, his focus shifted to the genetics of retroviruses.[13] Together with his associate Kumao Toyoshima, he isolated the first temperature sensitive mutants of a retrovirus and in collaboration with the biochemist Peter Duesberg discovered the first retroviral oncogene, src.[14] His work on mutants of the Rous sarcoma virus enabled Michael Bishop and Harold Varmus to isolate DNA sequences that represent the src oncogene and to demonstrate the cellular origin of oncogenes.[15] In his extensive studies on avian retroviruses, Vogt discovered oncogenes that play important roles in human cancers, e.g. myc (in collaboration with Bister and Duesberg),[16] jun (with Maki and Bos)[17] and p3k (with Chang).[18]

Vogt has received the Irene Vogeler Prize (1976), the Alexander von Humboldt Award (1984), the Ernst Jung Prize for Medicine (1985), the Robert J. and Claire Pasarow Award (1987), the Paul Ehrlich and Ludwig Darmstaedter Prize (1988), the Bristol Myers Award (1989), the Charles S. Mott Prize (1991) and the Albert Szent Györgyi Prize (2010).[19] He holds an honorary doctorate from the University of Würzburg (since 1995) and has been elected to several academies, including the National Academy of Sciences USA,[20] the American Philosophical Society,[21] the American Academy of Arts and Sciences, the German National Academy of Sciences Leopoldina[22] and the American Academy of Microbiology. He is on several scientific advisory and editorial boards, e. g. the Sidney Kimmel Foundation for Cancer Research (since 2005), the Proceedings of the National Academy of Sciences, USA (since 2000)[23] and Current Topics in Microbiology and Immunology (since 1967).

Vogt is also an avid painter. During his time in Würzburg, he studied with the artist Josef Versl.

References

  1. ↑ American Men and Women of Science, Thomson Gale
  2. ↑ Vogt, PK; Rubin H (1961). "Localization of infectious virus and viral antigen in chick fibroblasts during successive stages of infection with Rous sarcoma virus.". Virology 13: 528–44. doi:10.1016/0042-6822(61)90284-7. PMID 13781861.
  3. ↑ Rubin, H; Vogt PK (1962). "An avian leukosis virus associated with stocks of Rous sarcoma virus". Virology 17: 184–94. doi:10.1016/0042-6822(62)90096-x. PMID 14494905.
  4. ↑ Vogt, PK; Rubin H (1962). "The cytology of Rous sarcoma virus infection". Cold Spring Harb Symp Quant Biol. 27: 395–405. doi:10.1101/sqb.1962.027.001.037. PMID 13997686.
  5. ↑ "TSRI Faculty website".
  6. ↑ "TSRI press release".
  7. ↑ "TSRI Management".
  8. ↑ Ishizaki, R; Vogt PK. (1966). "Immunological relationships among envelope antigens of avian tumor viruses". Virology 30 (3): 375–87. doi:10.1016/0042-6822(66)90116-4. PMID 4288417.
  9. ↑ Vogt, PK; Ishizaki R (1966). Burdette, WJ, ed. "Criteria for the classification of avian tumor viruses". Viruses Inducing Cancer. Salt Lake City: University of Utah Press: 71–90.
  10. ↑ Vogt, PK; Ishizaki R (1966). "Patterns of viral interference in the avian leukosis and sarcoma complex". Virology 30 (3): 368–74. doi:10.1016/0042-6822(66)90115-2. PMID 4288416.
  11. ↑ Vogt, PK (1963). "The Cell Surface in Tumor Virus Infection". Cancer Res. 23: 1519–27. PMID 14072691.
  12. ↑ Vogt, PK; Luykx N (1963). "Observations on the surface of cells infected with Rous sarcoma virus". Virology 20: 75–87. doi:10.1016/0042-6822(63)90142-9. PMID 13997684.
  13. ↑ Toyoshima, K; Vogt PK (1969). "Temperature sensitive mutants of an avian sarcoma virus". Virology 39 (4): 930–1. doi:10.1016/0042-6822(69)90030-0. PMID 4311641.
  14. ↑ Duesberg, PH; Vogt PK (1970). "Differences between the ribonucleic acids of transforming and nontransforming avian tumor viruses". Proc Natl Acad Sci U S A 67 (4): 1673–80. doi:10.1073/pnas.67.4.1673. PMC 283411. PMID 4321342.
  15. ↑ "Nobel Prize 1989".
  16. ↑ Duesberg, PH; Bister K; Vogt PK (1977). "The RNA of avian acute leukemia virus MC29". Proc Natl Acad Sci U S A. 74 (10): 4320–4. doi:10.1073/pnas.74.10.4320. PMC 431932. PMID 200913.
  17. ↑ Maki, Y; Bos TJ; Davis C; Starbuck M; Vogt PK (1987). "Avian sarcoma virus 17 carries the jun oncogene". Proc Natl Acad Sci U S A 84 (9): 2848–52. doi:10.1073/pnas.84.9.2848. PMC 304757. PMID 3033666.
  18. ↑ Chang, HW; Aoki M; Fruman D; Auger KR; Bellacosa A; Tsichlis PN; Cantley LC; Roberts TM; Vogt PK (1997). "Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase". Science 276 (5320): 1848–50. doi:10.1126/science.276.5320.1848. PMID 9188528.
  19. ↑ "Dr. Peter K. Vogt: Recipient of the 5th Annual Szent-Györgyi Prize for Progress in Cancer Research".
  20. ↑ "NAS Member directory".
  21. ↑ "APS Member directory".
  22. ↑ "Leopoldina Member directory".
  23. ↑ "Peter K. Vogt: PNAS Editorial Board Member".

External links

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