Phthalyl amidase

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is phthalyl-amide amidohydrolase.

References

M (1996). "Discovery, purification, and properties of o-phthalyl amidase from Xanthobacter agilis". J. Mol. Catal., B Enzym. 2: 53–69. doi:10.1016/1381-1177(96)00011-2.
Zmijewski MJ; Briggs, Barbara S.; Evans, Robert; Muth, William L.; Vangala, Surya; Zmijewski, Milton J. (1996). "o-Phthalyl amidase in the synthesis of Loracarbef: process development using this novel biocatalyst". Biotechnol. Lett. 18: 875–880. doi:10.1007/BF00154613.
Costello C, Kreuzman A, Zmijewski M (1996). "Selective deprotection of phthalyl protected proteins". Tetrahedron Lett. 37: 7469–7472. doi:10.1016/0040-4039(96)01752-2.
Briggs BS, Zmijewski MJ (1995). "Enzyme from microbial source: phthalyl amidase". Chem. Abstr. 123: 25010.

Hydrolases: carbon-nitrogen non-peptide (EC 3.5)

3.5.1: Linear amides / Amidohydrolases	Asparaginase Glutaminase Urease Biotinidase Aspartoacylase Ceramidase Aspartylglucosaminidase Fatty acid amide hydrolase Histone deacetylase Sirtuin

3.5.2: Cyclic amides/ Amidohydrolases	Barbiturase Beta-lactamase

3.5.3: Linear amidines/ Ureohydrolases	Arginase Agmatinase Protein-arginine deiminase

3.5.4: Cyclic amidines/ Aminohydrolases	Guanine deaminase Adenosine deaminase AMP deaminase Inosine monophosphate synthase DCMP deaminase GTP cyclohydrolase I Cytidine deaminase AICDA Activation-induced cytidine deaminase

3.5.5: Nitriles/ Aminohydrolases	Nitrilase

3.5.99: Other	Riboflavinase Thiaminase II

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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