Picornavirus internal ribosome entry site (IRES)
Picornavirus internal ribosome entry site (IRES) | |
---|---|
Predicted secondary structure and sequence conservation of IRES_Picorna | |
Identifiers | |
Symbol | IRES_Picorna |
Rfam | RF00229 |
Other data | |
RNA type | Cis-reg; IRES |
Domain(s) | Viruses |
GO | 0043022 |
SO | 0000243 |
This family represents the Picornavirus internal ribosome entry site (IRES). IRES elements allow cap and end-independent translation of mRNA in the host cell. It has been found that La autoantigen (La) is required for Coxsackievirus B3 (CVB3) IRES-mediated translation, and it has been suggested that La may be required for the efficient translation of the viral RNA in the pancreas.[1][2]
References
- ↑ Ray, PS; Das S (2002). "La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA". Nucleic Acids Res 30 (20): 4500–4508. doi:10.1093/nar/gkf583. PMC 137146. PMID 12384597.
- ↑ Liu, Z; Carthy CM; Cheung P; Bohunek L; Wilson JE; McManus BM; Yang D (1999). "Structural and functional analysis of the 5' untranslated region of coxsackievirus B3 RNA: In vivo translational and infectivity studies of full-length mutants". Virology 265 (2): 206–217. doi:10.1006/viro.1999.0048. PMID 10600593.
External links
- http://rfam.xfam.org/family/RF00229 Picornavirus internal ribosome entry site (IRES)
- Page for Picornavirus internal ribosome entry site (IRES) at Rfam
This article is issued from Wikipedia - version of the Tuesday, May 03, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.