Presqualene diphosphate synthase

Presqualene diphosphate synthase (EC 2.5.1.103, SSL-1 (gene)) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate:(2E,6E)-farnesyl-diphosphate farnesyltransferase (presqualene diphosphate forming).^[1] This enzyme catalyses the following chemical reaction

2 (2E,6E)-farnesyl diphosphate

\rightleftharpoons

presqualene diphosphate + diphosphate

This enzyme is isolated from the green alga Botryococcus braunii BOT22.

References

↑ Niehaus, T.D., Okada, S., Devarenne, T.P., Watt, D.S., Sviripa, V. and Chappell, J. (2011). "Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii". Proc. Natl. Acad. Sci. USA 108 (30): 12260–12265. doi:10.1073/pnas.1106222108. PMC 3145686. PMID 21746901.

External links

Presqualene diphosphate synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferases: alkyl and aryl (EC 2.5)

2.5.1	Dimethylallyltranstransferase Thiaminase I Methionine adenosyltransferase Riboflavin synthase Dihydropteroate synthase Spermidine synthase Glutathione S-transferase Farnesyl-diphosphate farnesyltransferase Spermine synthase Alkylglycerone phosphate synthase Farnesyltransferase Geranylgeranyltransferase type 1 Porphobilinogen deaminase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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