Protein-serine epimerase

protein-serine epimerase
Identifiers
EC number	5.1.1.16
CAS number	169592-52-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a protein-serine epimerase (EC 5.1.1.16) is an enzyme that catalyzes the chemical reaction

[protein]-L-serine $\rightleftharpoons$ [protein]-D-serine

Hence, this enzyme has one substrate, [protein]-L-serine, and one product, [protein]-D-serine.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is [protein]-serine epimerase. This enzyme is also called protein-serine racemase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1WTC.

References

• Katayama K, Kuwada M (1995). "Isolation and characterization of a peptide isomerase from funnel web spider venom". J. Biol. Chem. 270 (28): 16719–23. doi:10.1074/jbc.270.28.16719. PMID 7622482.