Pseudaminic acid synthase

Pseudaminic acid synthase (EC 2.5.1.97, PseI, NeuB3) is an enzyme with systematic name phosphoenolpyruvate:2,4-bis(acetylamino)-2,4,6-trideoxy-beta-L-altropyranose transferase (phosphate-hydrolysing, 2,7-acetylamino-transferring, 2-carboxy-2-oxoethyl-forming).^[1] This enzyme catalyses the following chemical reaction

phosphoenolpyruvate + 2,4-bis(acetylamino)-2,4,6-trideoxy-beta-L-altropyranose + H₂O

\rightleftharpoons

5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid + phosphate

The enzyme requires a divalent metal ion, preferably Mn²⁺ and Co²⁺.

References

↑ Chou, W.K., Dick, S., Wakarchuk, W.W. and Tanner, M.E. (2005). "Identification and characterization of NeuB3 from Campylobacter jejuni as a pseudaminic acid synthase". J. Biol. Chem. 280 (43): 35922–35928. doi:10.1074/jbc.M507483200. PMID 16120604.

External links

Pseudaminic acid synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferases: alkyl and aryl (EC 2.5)

2.5.1	Dimethylallyltranstransferase Thiaminase I Methionine adenosyltransferase Riboflavin synthase Dihydropteroate synthase Spermidine synthase Glutathione S-transferase Farnesyl-diphosphate farnesyltransferase Spermine synthase Alkylglycerone phosphate synthase Farnesyltransferase Geranylgeranyltransferase type 1 Porphobilinogen deaminase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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