PurD RNA motif

purD RNA motif
Predicted secondary structure and sequence conservation of purD
Identifiers
Symbol purD
Rfam RF01069
Other data
RNA type Cis-reg
Domain(s) Bacteria
SO 0005836

The purD RNA motif is a conserved RNA structure found in epsilonproteobacteria, such as the genera Helicobacter and Campylobacter.[1] The RNA is consistently found in the apparent 5' UTR of purD genes. purD genes encode the enzyme Phosphoribosylamine-glycine ligase, which catalyzes an early step in de novo purine synthesis. Although a possible cis-regulatory role was proposed for this motif, experimental results indicate that it overlaps the 6S RNA of the relevant species,[2] and that the second hairpin of the motif might not be biological.

References

  1. Weinberg Z, Barrick JE, Yao Z, et al. (2007). "Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline". Nucleic Acids Res. 35 (14): 4809–19. doi:10.1093/nar/gkm487. PMC 1950547. PMID 17621584.
  2. Sharma CM, Hoffmann S, Darfeuille F, et al. (February 2010). "The primary transcriptome of the major human pathogen Helicobacter pylori". Nature 464 (7286): 250–5. doi:10.1038/nature08756. PMID 20164839.

External links


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