Putidaredoxin—NAD+ reductase

Putidaredoxin—NAD^+ reductase
Identifiers
EC number	1.18.1.5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Putidaredoxin—NAD⁺ reductase (EC 1.18.1.5, putidaredoxin reductase, camA (gene)) is an enzyme with systematic name putidaredoxin:NAD⁺ oxidoreductase.^{[1][2][3][4][5][6][7]} This enzyme catalyses the following chemical reaction

reduced putidaredoxin + NAD⁺ $\rightleftharpoons$ oxidized putidaredoxin + NADH + H⁺

Putidaredoxin—NAD⁺ reductase requires FAD.

References

1. Roome, P.W., Jr., Philley, J.C. and Peterson, J.A. (1983). "Purification and properties of putidaredoxin reductase". J. Biol. Chem. 258: 2593–2598. PMID 6401738.
2. Koga, H., Yamaguchi, E., Matsunaga, K., Aramaki, H. and Horiuchi, T. (1989). "Cloning and nucleotide sequences of NADH-putidaredoxin reductase gene (camA) and putidaredoxin gene (camB) involved in cytochrome P-450_cam hydroxylase of Pseudomonas putida". J. Biochem. 106: 831–836. PMID 2613690.
3. Peterson, J.A., Lorence, M.C. and Amarneh, B. (1990). "Putidaredoxin reductase and putidaredoxin. Cloning, sequence determination, and heterologous expression of the proteins". J. Biol. Chem. 265: 6066–6073. PMID 2180940.
4. Sevrioukova, I.F. and Poulos, T.L. (2002). "Putidaredoxin reductase, a new function for an old protein". J. Biol. Chem. 277: 25831–25839. doi:10.1074/jbc.m201110200. PMID 12011076.
5. Sevrioukova, I.F., Garcia, C., Li, H., Bhaskar, B. and Poulos, T.L. (2003). "Crystal structure of putidaredoxin, the [2Fe-2S] component of the P450_cam monooxygenase system from Pseudomonas putida". J. Mol. Biol. 333: 377–392. doi:10.1016/j.jmb.2003.08.028. PMID 14529624.
6. Sevrioukova, I.F., Li, H. and Poulos, T.L. (2004). "Crystal structure of putidaredoxin reductase from Pseudomonas putida, the final structural component of the cytochrome P450_cam monooxygenase". J. Mol. Biol. 336: 889–902. doi:10.1016/j.jmb.2003.12.067. PMID 15095867.
7. Smith, N., Mayhew, M., Holden, M.J., Kelly, H., Robinson, H., Heroux, A., Vilker, V.L. and Gallagher, D.T. (2004). "Structure of C73G putidaredoxin from Pseudomonas putida". Acta Crystallogr. D Biol. Crystallogr. 60: 816–822. doi:10.1107/s0907444904003348. PMID 15103126.

External links

• Putidaredoxin---NAD reductase at the US National Library of Medicine Medical Subject Headings (MeSH)