Drug-induced QT prolongation

Drug-induced QT prolongation is seen with a QT interval above 0.45 ms on the ECG and is usually a result of treatment by anti-arrhythmic drugs, such as amiodarone and sotalol, or a number of other drugs that have been reported to cause this problem (e.g., cisapride). Some anti-psychotic drugs, such as haloperidol and ziprasidone, have a prolonged QT interval as a rare side-effect. Antihistamines, erythromycin, and ciprofloxacin may also cause drug-induced LQT. Genetic mutations may make one more susceptible to drug-induced LQT. It is associated with hypokalaemia, hypocalcaemia and hypothermia and may lead to torsades de pointes.

List of drugs associated with prolonging the QT interval that may or may not have FDA warnings.[1]

See also

Footnotes

  1. ↑ Beach, Scott. "QTc prolongation, torsades de pointes, and psychotropic medications". Psychosomatics 54 (1): 1–13. doi:10.1016/j.psym.2012.11.001. PMID 23295003.

References

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