RAB11FIP5

RAB11 family interacting protein 5 (class I)
Identifiers
Symbols	RAB11FIP5 ; GAF1; RIP11; pp75
External IDs	OMIM: 605536 MGI: 1098586 HomoloGene: 9158 GeneCards: RAB11FIP5 Gene
Gene ontology Molecular function • protein binding • Rab GTPase binding • gamma-tubulin binding Cellular component • Golgi membrane • cytoplasm • mitochondrion • mitochondrial outer membrane • early endosome • Golgi apparatus • microtubule organizing center • secretory granule • transport vesicle membrane • early endosome membrane • intracellular membrane-bounded organelle • recycling endosome • recycling endosome membrane Biological process • insulin secretion involved in cellular response to glucose stimulus • regulated secretory pathway • negative regulation of adiponectin secretion • cellular response to acidic pH • regulation of protein localization to cell surface Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26056	52055
Ensembl	ENSG00000135631	ENSMUSG00000051343
UniProt	Q9BXF6	Q8R361
RefSeq (mRNA)	NM_015470	NM_001003955
RefSeq (protein)	NP_056285	NP_001003955
Location (UCSC)	Chr 2: 73.07 – 73.16 Mb	Chr 6: 85.33 – 85.37 Mb
PubMed search

Rab11 family-interacting protein 5 is a protein that in humans is encoded by the RAB11FIP5 gene.^[1][2][3]

Interactions

RAB11FIP5 has been shown to interact with RAB11A^[2][4][5] and RAB25.^[4][5]

References

1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
2. Prekeris R, Klumperman J, Scheller RH (February 2001). "A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes". Mol Cell 6 (6): 1437–48. doi:10.1016/S1097-2765(00)00140-4. PMID 11163216.
3. "Entrez Gene: RAB11FIP5 RAB11 family interacting protein 5 (class I)".
4. Hales, C M; Griner R; Hobdy-Henderson K C; Dorn M C; Hardy D; Kumar R; Navarre J; Chan E K; Lapierre L A; Goldenring J R (October 2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. (United States) 276 (42): 39067–75. doi:10.1074/jbc.M104831200. ISSN 0021-9258. PMID 11495908.
5. Prekeris, R; Davies J M; Scheller R H (October 2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J. Biol. Chem. (United States) 276 (42): 38966–70. doi:10.1074/jbc.M106133200. ISSN 0021-9258. PMID 11481332.

Further reading

• Wang D, Buyon JP, Zhu W, Chan EK (1999). "Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and identification of distinct human autoantibodies". J. Clin. Invest. 104 (9): 1265–75. doi:10.1172/JCI8003. PMC 409828. PMID 10545525.
• Chen D, Xu W, He P, et al. (2001). "Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria". J. Biol. Chem. 276 (16): 13127–35. doi:10.1074/jbc.M009424200. PMID 11278501.
• Prekeris R, Davies JM, Scheller RH (2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J. Biol. Chem. 276 (42): 38966–70. doi:10.1074/jbc.M106133200. PMID 11481332.
• Hales CM, Griner R, Hobdy-Henderson KC, et al. (2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. PMID 11495908.
• Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW (2003). "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells". Biochem. Biophys. Res. Commun. 299 (5): 770–9. doi:10.1016/S0006-291X(02)02720-1. PMID 12470645.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tani K, Shibata M, Kawase K, et al. (2003). "Mapping of functional domains of gamma-SNAP". J. Biol. Chem. 278 (15): 13531–8. doi:10.1074/jbc.M213205200. PMID 12554740.
• Kawase K, Shibata M, Kawashima H, et al. (2003). "Gaf-1b is an alternative splice variant of Gaf-1/Rip11". Biochem. Biophys. Res. Commun. 303 (4): 1042–6. doi:10.1016/S0006-291X(03)00486-8. PMID 12684040.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Schwenk RW, Luiken JJ, Eckel J (2007). "FIP2 and Rip11 specify Rab11a-mediated cellular distribution of GLUT4 and FAT/CD36 in H9c2-hIR cells". Biochem. Biophys. Res. Commun. 363 (1): 119–25. doi:10.1016/j.bbrc.2007.08.111. PMID 17854769.