RAB25

RAB25, member RAS oncogene family
PDB rendering based on 2oil.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2OIL​, 3TSO​
Identifiers
Symbols	RAB25 ; CATX-8; RAB11C
External IDs	OMIM: 612942 MGI: 1858203 HomoloGene: 22995 GeneCards: RAB25 Gene
Gene ontology Molecular function • GTPase activity • protein binding • GTP binding • myosin V binding Cellular component • cytoplasmic membrane-bounded vesicle • pseudopodium • pseudopodium membrane • cytoplasmic vesicle • recycling endosome • extracellular exosome Biological process • epithelial cell morphogenesis • intracellular protein transport • exocytosis • positive regulation of cell proliferation • positive regulation of epithelial cell migration • pseudopodium organization • melanosome transport • Rab protein signal transduction • regulation of vesicle-mediated transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57111	53868
Ensembl	ENSG00000132698	ENSMUSG00000008601
UniProt	P57735	Q9WTL2
RefSeq (mRNA)	NM_020387	NM_016899
RefSeq (protein)	NP_065120	NP_058595
Location (UCSC)	Chr 1: 156.06 – 156.07 Mb	Chr 3: 88.54 – 88.55 Mb
PubMed search

Ras-related protein Rab-25 is a protein that in humans is encoded by the RAB25 gene.^[1][2] It is thought to act as a promoter of tumor development.^[3]

Interactions

RAB25 has been shown to interact with RAB11FIP2^[4][5] and RAB11FIP5.^[4][5]

References

1. Pereira-Leal JB, Seabra MC (November 2001). "Evolution of the Rab family of small GTP-binding proteins". J Mol Biol 313 (4): 889–901. doi:10.1006/jmbi.2001.5072. PMID 11697911.
2. "Entrez Gene: RAB25 RAB25, member RAS oncogene family".
3. Kessler, D; Gruen, GC; Heider, D; Morgner, J; Reis, H; Schmid, KW; Jendrossek, V (2012). "The action of small GTPases Rab11 and Rab25 in vesicle trafficking during cell migration.". Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 29 (5-6): 647–56. PMID 22613965.
4. Hales, C M; Griner R; Hobdy-Henderson K C; Dorn M C; Hardy D; Kumar R; Navarre J; Chan E K; Lapierre L A; Goldenring J R (October 2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. (United States) 276 (42): 39067–75. doi:10.1074/jbc.M104831200. ISSN 0021-9258. PMID 11495908.
5. Prekeris, R; Davies J M; Scheller R H (October 2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J. Biol. Chem. (United States) 276 (42): 38966–70. doi:10.1074/jbc.M106133200. ISSN 0021-9258. PMID 11481332.

Further reading

• Goldenring JR, Shen KR, Vaughan HD, Modlin IM (1993). "Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung.". J. Biol. Chem. 268 (25): 18419–22. PMID 8360141.
• Ray GS, Lee JR, Nwokeji K, et al. (1997). "Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia.". Lab. Invest. 77 (5): 503–11. PMID 9389793.
• Lapierre LA, Kumar R, Hales CM, et al. (2001). "Myosin vb is associated with plasma membrane recycling systems.". Mol. Biol. Cell 12 (6): 1843–57. doi:10.1091/mbc.12.6.1843. PMC 37346. PMID 11408590.
• Prekeris R, Davies JM, Scheller RH (2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins.". J. Biol. Chem. 276 (42): 38966–70. doi:10.1074/jbc.M106133200. PMID 11481332.
• Hales CM, Griner R, Hobdy-Henderson KC, et al. (2001). "Identification and characterization of a family of Rab11-interacting proteins.". J. Biol. Chem. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. PMID 11495908.
• Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Fan Y, Xin XY, Chen BL, Ma X (2007). "Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo.". Pathology 38 (6): 561–7. doi:10.1080/00313020601024037. PMID 17393986.