RAB1A

RAB1A, member RAS oncogene family
PDB rendering based on 2fol.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2FOL​, 2WWX​, 3L0I​, 3SFV​, 3TKL​, 4FMB​, 4FMC​, 4FMD​, 4FME​, 4IRU​, 4JVS​
Identifiers
Symbols	RAB1A ; RAB1; YPT1
External IDs	OMIM: 179508 MGI: 97842 HomoloGene: 36154 GeneCards: RAB1A Gene
Gene ontology Molecular function • GTPase activity • protein binding • GTP binding Cellular component • Golgi membrane • early endosome • endoplasmic reticulum membrane • Golgi apparatus • cytosol • melanosome • extracellular exosome Biological process • autophagosome assembly • mitotic cell cycle • intracellular protein transport • ER to Golgi vesicle-mediated transport • endocytosis • autophagy • Golgi organization • vesicle-mediated transport • cell migration • virion assembly • growth hormone secretion • melanosome transport • Rab protein signal transduction • substrate adhesion-dependent cell spreading • cilium assembly • defense response to bacterium • vesicle transport along microtubule • interleukin-8 secretion • cargo loading into COPII-coated vesicle • establishment of endothelial intestinal barrier • positive regulation of glycoprotein metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5861	19324
Ensembl	ENSG00000138069	ENSMUSG00000020149
UniProt	P62820	P62821
RefSeq (mRNA)	NM_004161	NM_008996
RefSeq (protein)	NP_004152	NP_033022
Location (UCSC)	Chr 11: 66.27 – 66.28 Mb	Chr 11: 20.2 – 20.23 Mb
PubMed search

Ras-related protein Rab-1A is a protein that in humans is encoded by the RAB1A gene.^[1][2]

Interactions

RAB1A has been shown to interact with:

• CHML,^[3][4]
• GOLGA2,^[5][6][7]
• GOLGA5,^[8][9]
• MICAL1^[5]
• RABAC1,^[10][11] and
• CHM.^[3]

References

1. Zahraoui A, Touchot N, Chardin P, Tavitian A (Jul 1989). "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion". The Journal of Biological Chemistry 264 (21): 12394–401. PMID 2501306.
2. "Entrez Gene: RAB1A RAB1A, member RAS oncogene family".
3. Cremers FP, Armstrong SA, Seabra MC, Brown MS, Goldstein JL (Jan 1994). "REP-2, a Rab escort protein encoded by the choroideremia-like gene". The Journal of Biological Chemistry 269 (3): 2111–7. PMID 8294464.
4. Anant JS, Desnoyers L, Machius M, Demeler B, Hansen JC, Westover KD, Deisenhofer J, Seabra MC (Sep 1998). "Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex". Biochemistry 37 (36): 12559–68. doi:10.1021/bi980881a. PMID 9730828.
5. Weide T, Teuber J, Bayer M, Barnekow A (Jun 2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochemical and Biophysical Research Communications 306 (1): 79–86. PMID 12788069.
6. Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T (Nov 2001). "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER". FEBS Letters 508 (2): 201–9. PMID 11718716.
7. Short B, Preisinger C, Körner R, Kopajtich R, Byron O, Barr FA (Dec 2001). "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic". The Journal of Cell Biology 155 (6): 877–83. doi:10.1083/jcb.200108079. PMC 2150909. PMID 11739401.
8. Satoh A, Wang Y, Malsam J, Beard MB, Warren G (Mar 2003). "Golgin-84 is a rab1 binding partner involved in Golgi structure". Traffic 4 (3): 153–61. PMC 3282115. PMID 12656988.
9. Diao A, Rahman D, Pappin DJ, Lucocq J, Lowe M (Jan 2003). "The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation". The Journal of Cell Biology 160 (2): 201–12. doi:10.1083/jcb.200207045. PMC 2172652. PMID 12538640.
10. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
11. Martincic I, Peralta ME, Ngsee JK (Oct 1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". The Journal of Biological Chemistry 272 (43): 26991–8. PMID 9341137.

Further reading

• Bailly E, McCaffrey M, Touchot N, Zahraoui A, Goud B, Bornens M (Apr 1991). "Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2". Nature 350 (6320): 715–8. doi:10.1038/350715a0. PMID 1902553.
• Farnsworth CC, Seabra MC, Ericsson LH, Gelb MH, Glomset JA (Dec 1994). "Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A". Proceedings of the National Academy of Sciences of the United States of America 91 (25): 11963–7. doi:10.1073/pnas.91.25.11963. PMC 45356. PMID 7991565.
• Cremers FP, Armstrong SA, Seabra MC, Brown MS, Goldstein JL (Jan 1994). "REP-2, a Rab escort protein encoded by the choroideremia-like gene". The Journal of Biological Chemistry 269 (3): 2111–7. PMID 8294464.
• Karniguian A, Zahraoui A, Tavitian A (Aug 1993). "Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins". Proceedings of the National Academy of Sciences of the United States of America 90 (16): 7647–51. doi:10.1073/pnas.90.16.7647. PMC 47199. PMID 8356066.
• Wedemeyer N, Lengeling A, Ronsiek M, Korthaus D, Baer K, Wuttke M, Jockusch H (Mar 1996). "YAC contigs of the Rab1 and wobbler (wr) spinal muscular atrophy gene region on proximal mouse chromosome 11 and of the homologous region on human chromosome 2p". Genomics 32 (3): 447–54. doi:10.1006/geno.1996.0140. PMID 8838809.
• Martincic I, Peralta ME, Ngsee JK (Oct 1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". The Journal of Biological Chemistry 272 (43): 26991–8. doi:10.1074/jbc.272.43.26991. PMID 9341137.
• Anant JS, Desnoyers L, Machius M, Demeler B, Hansen JC, Westover KD, Deisenhofer J, Seabra MC (Sep 1998). "Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex". Biochemistry 37 (36): 12559–68. doi:10.1021/bi980881a. PMID 9730828.
• Bao S, Zhu J, Garvey WT (Nov 1998). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme 30 (11): 656–62. doi:10.1055/s-2007-978953. PMID 9918381.
• Allan BB, Moyer BD, Balch WE (Jul 2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science 289 (5478): 444–8. doi:10.1126/science.289.5478.444. PMID 10903204.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Moyer BD, Allan BB, Balch WE (Apr 2001). "Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tethering". Traffic 2 (4): 268–76. doi:10.1034/j.1600-0854.2001.1o007.x. PMID 11285137.
• Muslin AJ (Dec 2001). "Road Rage: Cardiac Rab1 and ER-to-Golgi Traffic". Circulation Research 89 (12): 1087–8. PMID 11739271.
• Short B, Preisinger C, Körner R, Kopajtich R, Byron O, Barr FA (Dec 2001). "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic". The Journal of Cell Biology 155 (6): 877–83. doi:10.1083/jcb.200108079. PMC 2150909. PMID 11739401.
• Diao A, Rahman D, Pappin DJ, Lucocq J, Lowe M (Jan 2003). "The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation". The Journal of Cell Biology 160 (2): 201–12. doi:10.1083/jcb.200207045. PMC 2172652. PMID 12538640.
• Satoh A, Wang Y, Malsam J, Beard MB, Warren G (Mar 2003). "Golgin-84 is a rab1 binding partner involved in Golgi structure". Traffic 4 (3): 153–61. doi:10.1034/j.1600-0854.2003.00103.x. PMID 12656988.
• Weide T, Teuber J, Bayer M, Barnekow A (Jun 2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochemical and Biophysical Research Communications 306 (1): 79–86. doi:10.1016/S0006-291X(03)00918-5. PMID 12788069.