RAB3C

RAB3C, member RAS oncogene family
Identifiers
Symbol	RAB3C
External IDs	OMIM: 612829 MGI: 1914545 HomoloGene: 23420 GeneCards: RAB3C Gene
Gene ontology Molecular function • GTPase activity • protein binding • GTP binding • myosin V binding Cellular component • endosome • cytosol • plasma membrane • synaptic vesicle • secretory granule membrane • vesicle • perinuclear region of cytoplasm Biological process • intracellular protein transport • vesicle docking involved in exocytosis • protein secretion • synaptic vesicle exocytosis • regulation of exocytosis • antigen processing and presentation • Rab protein signal transduction • protein localization to plasma membrane Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	115827	67295
Ensembl	ENSG00000152932	ENSMUSG00000021700
UniProt	Q96E17	P62823
RefSeq (mRNA)	NM_138453	NM_023852
RefSeq (protein)	NP_612462	NP_076341
Location (UCSC)	Chr 5: 58.58 – 58.86 Mb	Chr 13: 110.05 – 110.28 Mb
PubMed search

Ras-related protein Rab-3C is a protein that in humans is encoded by the RAB3C gene.^[1][2]

Interactions

Rab3C has been show to interact with ZWINT.^[3]

References

1. Cheng H, Ma Y, Ni X, Jiang M, Luo Y, Ying K, Xie Y, Ma Y (Aug 2002). "Cloning, mapping, and characterization of the human Rab3C gene". Biochemical Genetics 40 (7-8): 263–72. doi:10.1023/A:1019834901190. PMID 12296628.
2. "Entrez Gene: RAB3C RAB3C, member RAS oncogene family".
3. van Vlijmen T, Vleugel M, Evers M, Mohammed S, Wulf PS, Heck AJ, Hoogenraad CC, van der Sluijs P (Aug 2008). "A unique residue in rab3c determines the interaction with novel binding protein Zwint-1". FEBS Letters 582 (19): 2838–42. doi:10.1016/j.febslet.2008.07.012. PMID 18625232.

Further reading

• Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S (Jun 2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells". Proceedings of the National Academy of Sciences of the United States of America 101 (22): 8313–8. doi:10.1073/pnas.0306709101. PMC 420391. PMID 15159548.
• Fukuda M (Apr 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". The Journal of Biological Chemistry 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
• Schlüter OM, Khvotchev M, Jahn R, Südhof TC (Oct 2002). "Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion". The Journal of Biological Chemistry 277 (43): 40919–29. doi:10.1074/jbc.M203704200. PMID 12167638.
• Uphues I, Chern Y, Eckel J (Dec 1995). "Insulin-dependent translocation of the small GTP-binding protein rab3C in cardiac muscle: studies on insulin-resistant Zucker rats". FEBS Letters 377 (2): 109–12. doi:10.1016/0014-5793(95)01315-6. PMID 8543030.