ZWINT

ZW10 interacting kinetochore protein
Identifiers
Symbols ZWINT ; HZwint-1; KNTC2AP; SIP30; ZWINT1
External IDs OMIM: 609177 MGI: 1289227 HomoloGene: 48496 GeneCards: ZWINT Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 11130 52696
Ensembl ENSG00000122952 ENSMUSG00000019923
UniProt O95229 Q9CQU5
RefSeq (mRNA) NM_001005413 NM_001293683
RefSeq (protein) NP_001005413 NP_001280612
Location (UCSC) Chr 10:
56.36 – 56.36 Mb		 Chr 10:
72.65 – 72.67 Mb
PubMed search

ZW10 interactor (Zwint-1) is a protein that in humans is encoded by the ZWINT gene.[1]

Function

Zwint-1 is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[1]

Interactions

ZWINT has been shown to interact with MIS12.[2][3] ZWINT has also been shown to interact with RAB3C[4]

References

  1. 1 2 "Entrez Gene: ZWINT ZW10 interactor".
  2. ↑ Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
  3. ↑ Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821.
  4. ↑ van Vlijmen T, Vleugel M, Evers M, Mohammed S, Wulf PS, Heck AJ, Hoogenraad CC, van der Sluijs P (Aug 2008). "A unique residue in rab3c determines the interaction with novel binding protein Zwint-1". FEBS Letters 582 (19): 2838–42. doi:10.1016/j.febslet.2008.07.012. PMID 18625232.

Further reading

  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Starr DA, Saffery R, Li Z, Simpson AE, Choo KH, Yen TJ, Goldberg ML (Jun 2000). "HZwint-1, a novel human kinetochore component that interacts with HZW10". Journal of Cell Science. 113 ( Pt 11) (11): 1939–50. PMID 10806105. 
  • Musio A, Mariani T, Montagna C, Zambroni D, Ascoli C, Ried T, Vezzoni P (Apr 2004). "Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes". Gene 331: 33–40. doi:10.1016/j.gene.2004.01.028. PMID 15094189. 
  • Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340. 
  • Wang H, Hu X, Ding X, Dou Z, Yang Z, Shaw AW, Teng M, Cleveland DW, Goldberg ML, Niu L, Yao X (Dec 2004). "Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling". The Journal of Biological Chemistry 279 (52): 54590–8. doi:10.1074/jbc.M407588200. PMID 15485811. 
  • Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. 
  • Le XF, Lammayot A, Gold D, Lu Y, Mao W, Chang T, Patel A, Mills GB, Bast RC (Jan 2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". The Journal of Biological Chemistry 280 (3): 2092–104. doi:10.1074/jbc.M403080200. PMID 15504738. 
  • Kops GJ, Kim Y, Weaver BA, Mao Y, McLeod I, Yates JR, Tagaya M, Cleveland DW (Apr 2005). "ZW10 links mitotic checkpoint signaling to the structural kinetochore". The Journal of Cell Biology 169 (1): 49–60. doi:10.1083/jcb.200411118. PMC 1351127. PMID 15824131. 
  • Lin YT, Chen Y, Wu G, Lee WH (Nov 2006). "Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control". Oncogene 25 (52): 6901–14. doi:10.1038/sj.onc.1209687. PMID 16732327. 

External links


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