RAD21

RAD21 cohesin complex component
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RAD21 ; CDLS4; HR21; HRAD21; MCD1; NXP1; SCC1; hHR21
External IDs OMIM: 606462 MGI: 108016 HomoloGene: 38161 GeneCards: RAD21 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5885 19357
Ensembl ENSG00000164754 ENSMUSG00000022314
UniProt O60216 Q61550
RefSeq (mRNA) NM_006265 NM_009009
RefSeq (protein) NP_006256 NP_033035
Location (UCSC) Chr 8:
116.85 – 116.87 Mb
Chr 15:
51.96 – 51.99 Mb
PubMed search

Double-strand-break repair protein rad21 homolog is a protein that in humans is encoded by the RAD21 gene.[1][2]

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells.[2]

Interactions

RAD21 has been shown to interact with SMARCA5.[3]

See also

References

  1. McKay MJ, Troelstra C, van der Spek P, Kanaar R, Smit B, Hagemeijer A, Bootsma D, Hoeijmakers JH (Jan 1997). "Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse". Genomics 36 (2): 305–15. doi:10.1006/geno.1996.0466. PMID 8812457.
  2. 1 2 "Entrez Gene: RAD21 RAD21 homolog (S. pombe)".
  3. Hakimi, Mohamed-Ali; Bochar Daniel A; Schmiesing John A; Dong Yuanshu; Barak Orr G; Speicher David W; Yokomori Kyoko; Shiekhattar Ramin (Aug 2002). "A chromatin remodelling complex that loads cohesin onto human chromosomes". Nature (England) 418 (6901): 994–8. doi:10.1038/nature01024. ISSN 0028-0836. PMID 12198550.

Further reading

External links


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