SMARCA5

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Identifiers
Symbols	SMARCA5 ; ISWI; SNF2H; WCRF135; hISWI; hSNF2H
External IDs	OMIM: 603375 MGI: 1935129 HomoloGene: 55764 GeneCards: SMARCA5 Gene
Gene ontology Molecular function • DNA binding • helicase activity • protein binding • ATP binding • ATPase activity • nucleosome binding • histone binding Cellular component • condensed chromosome • nucleus • nucleoplasm • chromatin silencing complex • nucleolus • NURF complex • RSF complex • nuclear replication fork Biological process • chromatin silencing at rDNA • double-strand break repair • nucleosome assembly • chromatin remodeling • DNA-templated transcription, initiation • regulation of transcription from RNA polymerase II promoter • gene expression • nucleosome positioning • CENP-A containing nucleosome assembly • regulation of gene expression, epigenetic • ATP-dependent chromatin remodeling • negative regulation of gene expression, epigenetic Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8467	93762
Ensembl	ENSG00000153147	ENSMUSG00000031715
UniProt	O60264	Q91ZW3
RefSeq (mRNA)	NM_003601	NM_053124
RefSeq (protein)	NP_003592	NP_444354
Location (UCSC)	Chr 4: 143.51 – 143.56 Mb	Chr 8: 80.7 – 80.74 Mb
PubMed search

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 is a protein that in humans is encoded by the SMARCA5 gene.^[1][2]

Function

The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein.^[2]

Interactions

SMARCA5 has been shown to interact with RAD21,^[3] Histone deacetylase 2,^[3] POLE3,^[4] SATB1^[5] and BAZ1A.^{[3][4][5][6][7]}

References

1. Aihara T, Miyoshi Y, Koyama K, Suzuki M, Takahashi E, Monden M, Nakamura Y (October 1998). "Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human homologue of Drosophila ISWI". Cytogenetics and Cell Genetics 81 (3-4): 191–3. doi:10.1159/000015027. PMID 9730600.
2. "Entrez Gene: SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5".
3. Hakimi MA, Bochar DA, Schmiesing JA, Dong Y, Barak OG, Speicher DW, Yokomori K, Shiekhattar R (Aug 2002). "A chromatin remodelling complex that loads cohesin onto human chromosomes". Nature 418 (6901): 994–8. doi:10.1038/nature01024. PMID 12198550.
4. Poot RA, Dellaire G, Hülsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (Jul 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". The EMBO Journal 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.
5. Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T (Oct 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature 419 (6907): 641–5. doi:10.1038/nature01084. PMID 12374985.
6. Bochar DA, Savard J, Wang W, Lafleur DW, Moore P, Côté J, Shiekhattar R (Feb 2000). "A family of chromatin remodeling factors related to Williams syndrome transcription factor". Proceedings of the National Academy of Sciences of the United States of America 97 (3): 1038–43. doi:10.1073/pnas.97.3.1038. PMC 15513. PMID 10655480.
7. Bozhenok L, Wade PA, Varga-Weisz P (May 2002). "WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci". The EMBO Journal 21 (9): 2231–41. doi:10.1093/emboj/21.9.2231. PMC 125993. PMID 11980720.

Further reading

• Dirscherl SS, Krebs JE (Aug 2004). "Functional diversity of ISWI complexes". Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire 82 (4): 482–9. doi:10.1139/o04-044. PMID 15284901.
• LeRoy G, Orphanides G, Lane WS, Reinberg D (Dec 1998). "Requirement of RSF and FACT for transcription of chromatin templates in vitro". Science 282 (5395): 1900–4. doi:10.1126/science.282.5395.1900. PMID 9836642.
• Bochar DA, Savard J, Wang W, Lafleur DW, Moore P, Côté J, Shiekhattar R (Feb 2000). "A family of chromatin remodeling factors related to Williams syndrome transcription factor". Proceedings of the National Academy of Sciences of the United States of America 97 (3): 1038–43. doi:10.1073/pnas.97.3.1038. PMC 15513. PMID 10655480.
• Poot RA, Dellaire G, Hülsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (Jul 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". The EMBO Journal 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.
• Stopka T, Zakova D, Fuchs O, Kubrova O, Blafkova J, Jelinek J, Necas E, Zivny J (Jul 2000). "Chromatin remodeling gene SMARCA5 is dysregulated in primitive hematopoietic cells of acute leukemia". Leukemia 14 (7): 1247–52. doi:10.1038/sj.leu.2401807. PMID 10914549.
• Aalfs JD, Narlikar GJ, Kingston RE (Sep 2001). "Functional differences between the human ATP-dependent nucleosome remodeling proteins BRG1 and SNF2H". The Journal of Biological Chemistry 276 (36): 34270–8. doi:10.1074/jbc.M104163200. PMID 11435432.
• Strohner R, Nemeth A, Jansa P, Hofmann-Rohrer U, Santoro R, Längst G, Grummt I (Sep 2001). "NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines". The EMBO Journal 20 (17): 4892–900. doi:10.1093/emboj/20.17.4892. PMC 125270. PMID 11532953.
• Bozhenok L, Wade PA, Varga-Weisz P (May 2002). "WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci". The EMBO Journal 21 (9): 2231–41. doi:10.1093/emboj/21.9.2231. PMC 125993. PMID 11980720.
• Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE (Sep 2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Molecular and Cellular Biology 22 (17): 6070–8. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701.
• Hakimi MA, Bochar DA, Schmiesing JA, Dong Y, Barak OG, Speicher DW, Yokomori K, Shiekhattar R (Aug 2002). "A chromatin remodelling complex that loads cohesin onto human chromosomes". Nature 418 (6901): 994–8. doi:10.1038/nature01024. PMID 12198550.
• Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T (Oct 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature 419 (6907): 641–5. doi:10.1038/nature01084. PMID 12374985.
• Collins N, Poot RA, Kukimoto I, García-Jiménez C, Dellaire G, Varga-Weisz PD (Dec 2002). "An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin". Nature Genetics 32 (4): 627–32. doi:10.1038/ng1046. PMID 12434153.
• Loyola A, Huang JY, LeRoy G, Hu S, Wang YH, Donnelly RJ, Lane WS, Lee SC, Reinberg D (Oct 2003). "Functional analysis of the subunits of the chromatin assembly factor RSF". Molecular and Cellular Biology 23 (19): 6759–68. doi:10.1128/MCB.23.19.6759-6768.2003. PMC 193931. PMID 12972596.
• Shu H, Chen S, Bi Q, Mumby M, Brekken DL (Mar 2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line". Molecular & Cellular Proteomics 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
• Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (Feb 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096.
• Geiman TM, Sankpal UT, Robertson AK, Zhao Y, Zhao Y, Robertson KD (May 2004). "DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system". Biochemical and Biophysical Research Communications 318 (2): 544–55. doi:10.1016/j.bbrc.2004.04.058. PMID 15120635.
• Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.