SMARCA5

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Identifiers
Symbols SMARCA5 ; ISWI; SNF2H; WCRF135; hISWI; hSNF2H
External IDs OMIM: 603375 MGI: 1935129 HomoloGene: 55764 GeneCards: SMARCA5 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 8467 93762
Ensembl ENSG00000153147 ENSMUSG00000031715
UniProt O60264 Q91ZW3
RefSeq (mRNA) NM_003601 NM_053124
RefSeq (protein) NP_003592 NP_444354
Location (UCSC) Chr 4:
143.51 – 143.56 Mb
Chr 8:
80.7 – 80.74 Mb
PubMed search

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 is a protein that in humans is encoded by the SMARCA5 gene.[1][2]

Function

The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein.[2]

Interactions

SMARCA5 has been shown to interact with RAD21,[3] Histone deacetylase 2,[3] POLE3,[4] SATB1[5] and BAZ1A.[3][4][5][6][7]

References

  1. Aihara T, Miyoshi Y, Koyama K, Suzuki M, Takahashi E, Monden M, Nakamura Y (October 1998). "Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human homologue of Drosophila ISWI". Cytogenetics and Cell Genetics 81 (3-4): 191–3. doi:10.1159/000015027. PMID 9730600.
  2. 1 2 "Entrez Gene: SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5".
  3. 1 2 3 Hakimi MA, Bochar DA, Schmiesing JA, Dong Y, Barak OG, Speicher DW, Yokomori K, Shiekhattar R (Aug 2002). "A chromatin remodelling complex that loads cohesin onto human chromosomes". Nature 418 (6901): 994–8. doi:10.1038/nature01024. PMID 12198550.
  4. 1 2 Poot RA, Dellaire G, Hülsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (Jul 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". The EMBO Journal 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.
  5. 1 2 Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T (Oct 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature 419 (6907): 641–5. doi:10.1038/nature01084. PMID 12374985.
  6. Bochar DA, Savard J, Wang W, Lafleur DW, Moore P, Côté J, Shiekhattar R (Feb 2000). "A family of chromatin remodeling factors related to Williams syndrome transcription factor". Proceedings of the National Academy of Sciences of the United States of America 97 (3): 1038–43. doi:10.1073/pnas.97.3.1038. PMC 15513. PMID 10655480.
  7. Bozhenok L, Wade PA, Varga-Weisz P (May 2002). "WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci". The EMBO Journal 21 (9): 2231–41. doi:10.1093/emboj/21.9.2231. PMC 125993. PMID 11980720.

Further reading


This article is issued from Wikipedia - version of the Sunday, August 02, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.