RANBP9

RAN binding protein 9
Identifiers
Symbols RANBP9 ; BPM-L; BPM90; RANBPM; RanBP7
External IDs OMIM: 603854 MGI: 1928741 HomoloGene: 38057 GeneCards: RANBP9 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 10048 56705
Ensembl ENSG00000010017 ENSMUSG00000038546
UniProt Q96S59 P69566
RefSeq (mRNA) NM_005493 NM_019930
RefSeq (protein) NP_005484 NP_064314
Location (UCSC) Chr 6:
13.62 – 13.71 Mb
Chr 13:
43.4 – 43.48 Mb
PubMed search

Ran-binding protein 9 is a protein that in humans is encoded by the RANBP9 gene.[1][2]

Function

This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11.[2]

Interactions

RANBP9 has been shown to interact with:

References

  1. Nakamura M, Masuda H, Horii J, Kuma Ki, Yokoyama N, Ohba T, Nishitani H, Miyata T, Tanaka M, Nishimoto T (Dec 1998). "When Overexpressed, a Novel Centrosomal Protein, RanBPM, Causes Ectopic Microtubule Nucleation Similar to γ-Tubulin". J Cell Biol 143 (4): 1041–52. doi:10.1083/jcb.143.4.1041. PMC 2132962. PMID 9817760.
  2. 1 2 "Entrez Gene: RANBP9 RAN binding protein 9".
  3. 1 2 Rao MA, Cheng H, Quayle AN, Nishitani H, Nelson CC, Rennie PS (Dec 2002). "RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor". J. Biol. Chem. 277 (50): 48020–7. doi:10.1074/jbc.M209741200. PMID 12361945.
  4. Wang D, Li Z, Messing EM, Wu G (Sep 2002). "Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM". J. Biol. Chem. 277 (39): 36216–22. doi:10.1074/jbc.M205111200. PMID 12147692.
  5. Morris JA, Kandpal G, Ma L, Austin CP (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986.
  6. Zou Y, Lim S, Lee K, Deng X, Friedman E (Dec 2003). "Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M". J. Biol. Chem. 278 (49): 49573–81. doi:10.1074/jbc.M307556200. PMID 14500717.
  7. Wang Y, Marion Schneider E, Li X, Duttenhöfer I, Debatin K, Hug H (Sep 2002). "HIPK2 associates with RanBPM". Biochem. Biophys. Res. Commun. 297 (1): 148–53. doi:10.1016/S0006-291X(02)02020-X. PMID 12220523.
  8. Umeda M, Nishitani H, Nishimoto T (Jan 2003). "A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM". Gene 303: 47–54. doi:10.1016/s0378-1119(02)01153-8. PMID 12559565.
  9. Emberley ED, Gietz RD, Campbell JD, HayGlass KT, Murphy LC, Watson PH (Nov 2002). "RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer". BMC Cancer 2: 28. doi:10.1186/1471-2407-2-28. PMC 137593. PMID 12421467.
  10. Ideguchi H, Ueda A, Tanaka M, Yang J, Tsuji T, Ohno S, Hagiwara E, Aoki A, Ishigatsubo Y (Oct 2002). "Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM". Biochem. J. 367 (Pt 1): 87–95. doi:10.1042/BJ20011851. PMC 1222860. PMID 12084015.

Further reading

External links


This article is issued from Wikipedia - version of the Wednesday, September 02, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.