RNF11

Ring finger protein 11
Identifiers
Symbols	RNF11 ; CGI-123; SID1669
External IDs	OMIM: 612598 MGI: 1352759 HomoloGene: 32195 GeneCards: RNF11 Gene
Gene ontology Molecular function • DNA binding • ubiquitin-protein transferase activity • protein binding • zinc ion binding Cellular component • ubiquitin ligase complex • nucleus • early endosome • recycling endosome • extracellular exosome Biological process • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • protein autoubiquitination Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26994	29864
Ensembl	ENSG00000123091	ENSMUSG00000028557
UniProt	Q9Y3C5	Q9QYK7
RefSeq (mRNA)	NM_014372	NM_013876
RefSeq (protein)	NP_055187	NP_038904
Location (UCSC)	Chr 1: 51.24 – 51.27 Mb	Chr 4: 109.45 – 109.48 Mb
PubMed search

RING finger protein 11 is a protein that in humans is encoded by the RNF11 gene.^[1][2][3]

Function

The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).^[3]

See also

• RING finger domain

Interactions

RNF11 has been shown to interact with RIPK1^[4] and STAMBP.^[5]

References

1. Seki N, Hattori A, Hayashi A, Kozuma S, Sasaki M, Suzuki Y, Sugano S, Muramatsu MA, Saito T (March 2000). "Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein". Biochim. Biophys. Acta 1489 (2-3): 421–7. doi:10.1016/s0167-4781(99)00190-6. PMID 10673045. Check date values in: |year= / |date= mismatch (help)
2. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (August 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
3. "Entrez Gene: RNF11 ring finger protein 11".
4. Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW (March 2009). "The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling". EMBO J. 28 (5): 513–22. doi:10.1038/emboj.2008.285. PMC 2657574. PMID 19131965.
5. Li H, Seth A (March 2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250.

Further reading

• Burger A, Amemiya Y, Kitching R, Seth AK (2006). "Novel RING E3 ubiquitin ligases in breast cancer". Neoplasia 8 (8): 689–95. doi:10.1593/neo.06469. PMC 1601945. PMID 16925951.
• Jolliffe CN, Harvey KF, Haines BP, Parasivam G, Kumar S (2000). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". Biochem. J. 351 Pt 3: 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394. PMID 11042109.
• Watanabe T, Ichihara M, Hashimoto M, Shimono K, Shimoyama Y, Nagasaka T, Murakumo Y, Murakami H, Sugiura H, Iwata H, Ishiguro N, Takahashi M (2002). "Characterization of gene expression induced by RET with MEN2A or MEN2B mutation". Am. J. Pathol. 161 (1): 249–56. doi:10.1016/S0002-9440(10)64176-4. PMC 1850689. PMID 12107109.
• Kitching R, Wong MJ, Koehler D, Burger AM, Landberg G, Gish G, Seth A (2003). "The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases". Biochim. Biophys. Acta 1639 (2): 104–12. doi:10.1016/j.bbadis.2003.07.001. PMID 14559117.
• Subramaniam V, Li H, Wong M, Kitching R, Attisano L, Wrana J, Zubovits J, Burger AM, Seth A (2003). "The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase". Br. J. Cancer 89 (8): 1538–44. doi:10.1038/sj.bjc.6601301. PMC 2394340. PMID 14562029.
• Li H, Seth A (2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Connor MK, Azmi PB, Subramaniam V, Li H, Seth A (2005). "Molecular characterization of ring finger protein 11". Mol. Cancer Res. 3 (8): 453–61. doi:10.1158/1541-7786.MCR-04-0166. PMID 16123141.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Anderson LR, Betarbet R, Gearing M, Gulcher J, Hicks AA, Stefánsson K, Lah JJ, Levey AI (2007). "PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain". J. Neuropathol. Exp. Neurol. 66 (10): 955–64. doi:10.1097/nen.0b013e3181567f17. PMID 17917589.

External links

• RNF11 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)