STAMBP

STAM binding protein
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2XZE​, 3RZU​, 3RZV​
Identifiers
Symbols	STAMBP ; AMSH; MICCAP
External IDs	OMIM: 606247 MGI: 1917777 HomoloGene: 4719 GeneCards: STAMBP Gene
EC number	3.1.2.15
Gene ontology Molecular function • ubiquitin-specific protease activity • protein binding • metallopeptidase activity • protein domain specific binding • metal ion binding Cellular component • nucleus • nucleoplasm • cytoplasm • early endosome • plasma membrane • cleavage furrow • extracellular exosome Biological process • mitotic cytokinesis • JAK-STAT cascade • positive regulation of cell proliferation • negative regulation of phosphatidylinositol 3-kinase signaling • protein deubiquitination • negative regulation of neuron apoptotic process • negative regulation of Ras protein signal transduction Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10617	70527
Ensembl	ENSG00000124356	ENSMUSG00000006906
UniProt	O95630	Q9CQ26
RefSeq (mRNA)	NM_006463	NM_024239
RefSeq (protein)	NP_006454	NP_077201
Location (UCSC)	Chr 2: 73.83 – 73.87 Mb	Chr 6: 83.54 – 83.57 Mb
PubMed search

STAM-binding protein is a protein that in humans is encoded by the STAMBP gene.^[1][2]

Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.^[2]

Mutations in this gene have been associated to cases of microcephaly (doi:10.1038/ng.2602)

Interactions

STAMBP has been shown to interact with RNF11,^[3] Signal transducing adaptor molecule^[1][4] and GRAP2.^[5][6]

References

1. Tanaka N, Kaneko K, Asao H, Kasai H, Endo Y, Fujita T, Takeshita T, Sugamura K (July 1999). "Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines". J Biol Chem 274 (27): 19129–35. doi:10.1074/jbc.274.27.19129. PMID 10383417.
2. "Entrez Gene: STAMBP STAM binding protein".
3. Li, Haoxia; Seth Arun (March 2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene (England) 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. ISSN 0950-9232. PMID 14755250.
4. Kato, M; Miyazawa K; Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". J. Biol. Chem. (United States) 275 (48): 37481–7. doi:10.1074/jbc.M007251200. ISSN 0021-9258. PMID 10982817.
5. Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. Cite uses deprecated parameter |coauthors= (help)
6. Asada, H; Ishii N; Sasaki Y; Endo K; Kasai H; Tanaka N; Takeshita T; Tsuchiya S; Konno T; Sugamura K (May 1999). "Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT". J. Exp. Med. (United States) 189 (9): 1383–90. doi:10.1084/jem.189.9.1383. ISSN 0022-1007. PMC 2193052. PMID 10224278.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Asada H, Ishii N, Sasaki Y, et al. (1999). "Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT.". J. Exp. Med. 189 (9): 1383–90. doi:10.1084/jem.189.9.1383. PMC 2193052. PMID 10224278.
• Endo K, Takeshita T, Kasai H, et al. (2000). "STAM2, a new member of the STAM family, binding to the Janus kinases.". FEBS Lett. 477 (1-2): 55–61. doi:10.1016/S0014-5793(00)01760-9. PMID 10899310.
• Itoh F, Asao H, Sugamura K, et al. (2001). "Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads.". EMBO J. 20 (15): 4132–42. doi:10.1093/emboj/20.15.4132. PMC 149146. PMID 11483516.
• Ishii N, Owada Y, Yamada M, et al. (2001). "Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice.". Mol. Cell. Biol. 21 (24): 8626–37. doi:10.1128/MCB.21.24.8626-8637.2001. PMC 100023. PMID 11713295.
• Maytal-Kivity V, Reis N, Hofmann K, Glickman MH (2006). "MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function.". BMC Biochem. 3: 28. doi:10.1186/1471-2091-3-28. PMC 129983. PMID 12370088.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ibarrola N, Kratchmarova I, Nakajima D, et al. (2004). "Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling.". BMC Cell Biol. 5: 2. doi:10.1186/1471-2121-5-2. PMC 385422. PMID 14728725.
• Ambroggio XI, Rees DC, Deshaies RJ (2006). "JAMM: a metalloprotease-like zinc site in the proteasome and signalosome.". PLoS Biol. 2 (1): E2. doi:10.1371/journal.pbio.0020002. PMC 300881. PMID 14737182.
• Li H, Seth A (2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein.". Oncogene 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250.
• McCullough J, Clague MJ, Urbé S (2004). "AMSH is an endosome-associated ubiquitin isopeptidase.". J. Cell Biol. 166 (4): 487–92. doi:10.1083/jcb.200401141. PMC 2172215. PMID 15314065.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Row PE, Prior IA, McCullough J, et al. (2006). "The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation.". J. Biol. Chem. 281 (18): 12618–24. doi:10.1074/jbc.M512615200. PMID 16520378.
• Nakamura M, Tanaka N, Kitamura N, Komada M (2006). "Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes.". Genes Cells 11 (6): 593–606. doi:10.1111/j.1365-2443.2006.00963.x. PMID 16716190.
• Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.". Genomics 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.