RNPEP

Arginyl aminopeptidase (aminopeptidase B)
Identifiers
Symbols	RNPEP ; DKFZP547H084
External IDs	OMIM: 602675 MGI: 2384902 HomoloGene: 10628 ChEMBL: 2432 GeneCards: RNPEP Gene
EC number	3.4.11.6
Gene ontology Molecular function • aminopeptidase activity • epoxide hydrolase activity • metalloexopeptidase activity • zinc ion binding • peptide binding • metalloaminopeptidase activity Cellular component • extracellular region • extracellular space • plasma membrane • secretory granule • extracellular exosome Biological process • proteolysis • leukotriene biosynthetic process • peptide catabolic process • negative regulation of blood pressure Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6051	215615
Ensembl	ENSG00000176393	ENSMUSG00000041926
UniProt	Q9H4A4	Q8VCT3
RefSeq (mRNA)	NM_020216	NM_001159624
RefSeq (protein)	NP_064601	NP_001153096
Location (UCSC)	Chr 1: 201.98 – 202.01 Mb	Chr 1: 135.26 – 135.28 Mb
PubMed search

Aminopeptidase B is an enzyme that in humans is encoded by the RNPEP gene.^[1][2][3]

References

1. Aurich-Costa J, Cadel S, Gouzy C, Foulon T, Cherif D, Cohen P (Apr 1998). "Assignment of the aminopeptidase B gene (RNPEP) to human chromosome 1 band q32 by in situ hybridization". Cytogenet Cell Genet 79 (1–2): 143–4. doi:10.1159/000134703. PMID 9533033.
2. Foulon T, Cadel S, Cohen P (Oct 1999). "Aminopeptidase B (EC 3.4.11.6)". Int J Biochem Cell Biol 31 (7): 747–50. doi:10.1016/S1357-2725(99)00021-7. PMID 10467730.
3. "Entrez Gene: RNPEP arginyl aminopeptidase (aminopeptidase B)".

Further reading

• Belhacene N, Mari B, Rossi B, Auberger P (1993). "Characterization and purification of T lymphocyte aminopeptidase B: a putative marker of T cell activation". Eur. J. Immunol. 23 (8): 1948–55. doi:10.1002/eji.1830230833. PMID 8344358.
• Gress TM, Müller-Pillasch F, Geng M, et al. (1996). "A pancreatic cancer-specific expression profile". Oncogene 13 (8): 1819–30. PMID 8895530.
• Balogh A, Cadel S, Foulon T, et al. (1998). "Aminopeptidase B: a processing enzyme secreted and associated with the plasma membrane of rat pheochromocytoma (PC12) cells". J. Cell. Sci. 111 (2): 161–9. PMID 9405297.
• Piesse C, Tymms M, Garrafa E, et al. (2002). "Human aminopeptidase B (rnpep) on chromosome 1q32.2: complementary DNA, genomic structure and expression". Gene 292 (1–2): 129–40. doi:10.1016/S0378-1119(02)00650-9. PMID 12119107.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fukasawa KM, Hirose J, Hata T, Ono Y (2006). "Aspartic acid 405 contributes to the substrate specificity of aminopeptidase B". Biochemistry 45 (38): 11425–31. doi:10.1021/bi0604577. PMID 16981702.

External links

• The MEROPS online database for peptidases and their inhibitors: M01.014