HslU—HslV peptidase

HslU—HslV peptidase
Identifiers
EC number	3.4.25.2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

HslU—HslV peptidase (EC 3.4.25.2, HslUV, HslV-HslU, HslV peptidase, ATP-dependent HslV-HslU proteinase, caseinolytic protease X, caseinolytic proteinase X, ClpXP ATP-dependent protease, ClpXP protease, ClpXP serine proteinase, Escherichia coli ClpXP serine proteinase, HslUV protease, HslUV proteinase, HslVU protease, HslVU proteinase, protease HslVU, proteinase HslUV) is an enzyme.^{[1][2][3][4][5][6][7]} This enzyme catalyses the following chemical reaction

ATP-dependent cleavage of peptide bonds with broad specificity.

This enzyme belongs to the peptidase family T1.

References

1. Wang, J., Rho, S.H., Park, H.H. and Eom, S.H. (2005). "Correction of X-ray intensities from an HslV-HslU co-crystal containing lattice-translocation defects". Acta Crystallogr. D Biol. Crystallogr. 61: 932–941. doi:10.1107/s0907444905009546. PMID 15983416.
2. Nishii, W. and Takahashi, K. (2003). "Determination of the cleavage sites in SulA, a cell division inhibitor, by the ATP-dependent HslVU protease from Escherichia coli". FEBS Lett. 553: 351–354. doi:10.1016/s0014-5793(03)01044-5. PMID 14572649.
3. Ramachandran, R., Hartmann, C., Song, H.K., Huber, R. and Bochtler, M. (2002). "Functional interactions of HslV (ClpQ) with the ATPase HslU (ClpY)". Proc. Natl. Acad. Sci. USA 99: 7396–7401. doi:10.1073/pnas.102188799. PMID 12032294.
4. Yoo, S.J., Seol, J.H., Shin, D.H., Rohrwild, M., Kang, M.S., Tanaka, K., Goldberg, A.L. and Chung, C.H. (1996). "Purification and characterization of the heat shock proteins HslV and HslU that form a new ATP-dependent protease in Escherichia coli". J. Biol. Chem. 271: 14035–14040. doi:10.1074/jbc.271.24.14035. PMID 8662828.
5. Yoo, S.J., Seol, J.H., Seong, I.S., Kang, M.S. and Chung, C.H. (1997). "ATP binding, but not its hydrolysis, is required for assembly and proteolytic activity of the HslVU protease in Escherichia coli". Biochem. Biophys. Res. Commun. 238: 581–585. doi:10.1006/bbrc.1997.7341. PMID 9299555.
6. Kanemori, M., Nishihara, K., Yanagi, H. and Yura, T. (1997). "Synergistic roles of HslVU and other ATP-dependent proteases in controlling in vivo turnover of σ³² and abnormal proteins in Escherichia coli". J. Bacteriol. 179: 7219–7225. PMID 9393683.
7. Burton, R.E., Baker, T.A. and Sauer, R.T. (2005). "Nucleotide-dependent substrate recognition by the AAA⁺ HslUV protease". Nat. Struct. Mol. Biol. 12: 245–251. doi:10.1038/nsmb898. PMID 15696175.

External links

• HslU---HslV peptidase at the US National Library of Medicine Medical Subject Headings (MeSH)