RNase E 5' UTR element
| RNase E 5' UTR element | |
|---|---|
 | |
| Predicted secondary structure and sequence conservation of rne5 | |
| Identifiers | |
| Symbol | rne5 |
| Rfam | RF00040 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Bacteria |
| SO | 0000204 |
In molecular biology, the RNase E 5' UTR element is a cis-acting element located in the 5'UTR of ribonuclease (RNase) E messenger RNA (mRNA).
RNase E is a key regulatory enzyme in the pathway of mRNA degradation in Escherichia coli. It is able to auto-regulate the degradation of its own mRNA in response to changes in RNase E activity. This rne 5' UTR element acts as a sensor of cellular RNase E concentration enabling tight regulation of RNase E concentration and synthesis.[1]
References
- ↑ Diwa A, Bricker AL, Jain C, Belasco JG (2000). "An evolutionarily conserved RNA stem–loop functions as a sensor that directs feedback regulation of RNase E gene expression". Genes Dev. 14 (10): 1249–60. PMC 316614. PMID 10817759.
See also
External links
This article is issued from Wikipedia - version of the Monday, October 17, 2011. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.