MST4

Serine/threonine protein kinase 26
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3GGF​, 3W8I​, 4FZA​, 4FZD​, 4FZF​, 4GEH​
Identifiers
Symbols	STK26 ; MASK; MST4
External IDs	OMIM: 300547 MGI: 1917665 HomoloGene: 84402 ChEMBL: 5941 GeneCards: STK26 Gene
EC number	2.7.11.1
Gene ontology Molecular function • magnesium ion binding • protein kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • identical protein binding • protein homodimerization activity Cellular component • Golgi membrane • nucleus • nucleoplasm • cytoplasm • Golgi apparatus • Golgi-associated vesicle • centrosome • cytosol • apical plasma membrane • perinuclear region of cytoplasm • extracellular exosome • cell periphery Biological process • protein phosphorylation • apoptotic process • cellular component disassembly involved in execution phase of apoptosis • regulation of mitotic cell cycle • programmed cell death • signal transduction by protein phosphorylation • microvillus assembly • stress-activated protein kinase signaling cascade • activation of protein kinase activity • response to hydrogen peroxide • regulation of apoptotic process • protein autophosphorylation • regulation of hydrogen peroxide-induced cell death Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51765	70415
Ensembl	ENSG00000134602	ENSMUSG00000031112
UniProt	Q9P289	Q99JT2
RefSeq (mRNA)	NM_001042452	NM_133729
RefSeq (protein)	NP_001035917	NP_598490
Location (UCSC)	Chr X: 132.02 – 132.08 Mb	Chr X: 50.84 – 50.89 Mb
PubMed search

Serine/threonine protein kinase MST4, also known as mammalian STE20-like protein kinase 4 (MST-4), is a protein that in humans is encoded by the MST4 gene.^[1]

Function

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[1]

Interactions

RP6-213H19.1 has been shown to interact with:

• CTTNBP2NL,^[2]
• CTTNBP2,^[2]
• FAM40A,^[2]
• MOBKL3,^[2]
• PDCD10,^[2]
• STRN3,^[2] and
• STRN.^[2]

References

1. "Entrez Gene: RP6-213H19.1 serine/threonine protein kinase MST4".
2. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (January 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

Further reading

• Liu KC, Wang D (1975). "[Synthesis of n-substituted beta-methyl DL-aspartates as potential hypocholesteremics (author's transl)]". Arch. Pharm. (Weinheim) 308 (7): 564–70. PMID 1164178.
• Qian Z, Lin C, Espinosa R, LeBeau M, Rosner MR (2001). "Cloning and characterization of MST4, a novel Ste20-like kinase". J. Biol. Chem. 276 (25): 22439–45. doi:10.1074/jbc.M009323200. PMID 11306563.
• Dan I, Watanabe NM, Kusumi A (2001). "The Ste20 group kinases as regulators of MAP kinase cascades". Trends Cell Biol. 11 (5): 220–30. doi:10.1016/S0962-8924(01)01980-8. PMID 11316611.
• Lin JL, Chen HC, Fang HI, Robinson D, Kung HJ, Shih HM (2001). "MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway". Oncogene 20 (45): 6559–69. doi:10.1038/sj.onc.1204818. PMID 11641781.
• Dan I, Ong SE, Watanabe NM, Blagoev B, Nielsen MM, Kajikawa E, Kristiansen TZ, Mann M, Pandey A (2002). "Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties". J. Biol. Chem. 277 (8): 5929–39. doi:10.1074/jbc.M110882200. PMID 11741893.
• Sung V, Luo W, Qian D, Lee I, Jallal B, Gishizky M (2003). "The Ste20 kinase MST4 plays a role in prostate cancer progression". Cancer Res. 63 (12): 3356–63. PMID 12810671.
• Preisinger C, Short B, De Corte V, Bruyneel E, Haas A, Kopajtich R, Gettemans J, Barr FA (2004). "YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta". J. Cell Biol. 164 (7): 1009–20. doi:10.1083/jcb.200310061. PMC 2172068. PMID 15037601.
• Chan EH, Nousiainen M, Chalamalasetty RB, Schäfer A, Nigg EA, Silljé HH (2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1". Oncogene 24 (12): 2076–86. doi:10.1038/sj.onc.1208445. PMID 15688006.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Ma X, Zhao H, Shan J, Long F, Chen Y, Chen Y, Zhang Y, Han X, Ma D (2007). "PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway". Mol. Biol. Cell 18 (6): 1965–78. doi:10.1091/mbc.E06-07-0608. PMC 1877091. PMID 17360971.