STRN

Striatin, calmodulin binding protein
Identifiers
Symbols	STRN ; SG2NA
External IDs	OMIM: 614765 MGI: 1333757 HomoloGene: 2380 GeneCards: STRN Gene
Gene ontology Molecular function • protein binding • calmodulin binding • estrogen receptor binding • protein complex binding • protein phosphatase 2A binding • armadillo repeat domain binding Cellular component • protein phosphatase type 2A complex • cytoplasm • bicellular tight junction • postsynaptic density • membrane • neuronal cell body • dendritic spine • postsynaptic membrane Biological process • locomotory behavior • negative regulation of cell proliferation • Wnt signaling pathway • dendrite development • bicellular tight junction assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6801	268980
Ensembl	ENSG00000115808	ENSMUSG00000024077
UniProt	O43815	O55106
RefSeq (mRNA)	NM_003162	NM_011500
RefSeq (protein)	NP_003153	NP_035630
Location (UCSC)	Chr 2: 36.84 – 36.97 Mb	Chr 17: 78.65 – 78.74 Mb
PubMed search

Striatin is a protein that in humans is encoded by the STRN gene.^[1][2][3]

Interactions

STRN has been shown to interact with:

• CTTNBP2NL,^[4]
• CTTNBP2,^[4]
• FAM40A,^[4]
• MOBKL3,^[4]
• PDCD10,^[4]
• PPP2CA,^[4]
• PPP2R1A,^[4]
• RP6-213H19.1,^[4]
• STK24,^[4][5]
• STK25,^[4]
• STRN3,^[4] and
• TRAF3IP3.^[4]

References

1. Moqrich A, Mattei MG, Bartoli M, Rakitina T, Baillat G, Monneron A, Castets F (Jul 1998). "Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain". Genomics 51 (1): 136–9. doi:10.1006/geno.1998.5342. PMID 9693043.
2. Castets F, Bartoli M, Barnier JV, Baillat G, Salin P, Moqrich A, Bourgeois JP, Denizot F, Rougon G, Calothy G, Monneron A (Aug 1996). "A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons". The Journal of Cell Biology 134 (4): 1051–62. doi:10.1083/jcb.134.4.1051. PMC 2120968. PMID 8769426.
3. "Entrez Gene: STRN striatin, calmodulin binding protein".
4. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
5. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

• Moreno CS, Park S, Nelson K, Ashby D, Hubalek F, Lane WS, Pallas DC (Feb 2000). "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A". The Journal of Biological Chemistry 275 (8): 5257–63. doi:10.1074/jbc.275.8.5257. PMC 3505218. PMID 10681496.
• Gaillard S, Bartoli M, Castets F, Monneron A (Nov 2001). "Striatin, a calmodulin-dependent scaffolding protein, directly binds caveolin-1". FEBS Letters 508 (1): 49–52. doi:10.1016/S0014-5793(01)03020-4. PMID 11707266.
• Huang Y, Tang R, Dai J, Gu S, Zhao W, Cheng C, Xu M, Zhou Z, Ying K, Xi Y, Mao Y (2002). "A novel human hydroxysteroid dehydrogenase like 1 gene (HSDL1) is highly expressed in reproductive tissues". Molecular Biology Reports 28 (4): 185–91. doi:10.1023/A:1015726217890. PMID 12153137.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Lu Q, Pallas DC, Surks HK, Baur WE, Mendelsohn ME, Karas RH (Dec 2004). "Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha". Proceedings of the National Academy of Sciences of the United States of America 101 (49): 17126–31. doi:10.1073/pnas.0407492101. PMC 534607. PMID 15569929.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.