STK25

Serine/threonine kinase 25
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2XIK​, 3W8H​, 4NZW​
Identifiers
Symbols	STK25 ; SOK1; YSK1
External IDs	OMIM: 602255 MGI: 1891699 HomoloGene: 48428 ChEMBL: 5552 GeneCards: STK25 Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • protein homodimerization activity • metal ion binding Cellular component • Golgi membrane • cytoplasm • Golgi apparatus • extracellular exosome Biological process • protein phosphorylation • response to oxidative stress • establishment or maintenance of cell polarity • signal transduction • regulation of mitotic cell cycle • signal transduction by protein phosphorylation • stress-activated protein kinase signaling cascade • activation of protein kinase activity • positive regulation of stress-activated MAPK cascade • intrinsic apoptotic signaling pathway in response to hydrogen peroxide • response to hydrogen peroxide • regulation of apoptotic process • protein autophosphorylation • positive regulation of axonogenesis • Golgi localization • establishment of Golgi localization • Golgi reassembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10494	59041
Ensembl	ENSG00000115694	ENSMUSG00000026277
UniProt	O00506	Q9Z2W1
RefSeq (mRNA)	NM_001271977	NM_021537
RefSeq (protein)	NP_001258906	NP_067512
Location (UCSC)	Chr 2: 241.49 – 241.51 Mb	Chr 1: 93.62 – 93.66 Mb
PubMed search

Serine/threonine-protein kinase 25 is an enzyme that in humans is encoded by the STK25 gene.^[1][2][3][4]

Interactions

STK25 has been shown to interact with STRN,^[5] PDCD10^[6] and MOBKL3.^[5]

References

1. Pombo CM, Bonventre JV, Molnar A, Kyriakis J, Force T (Jan 1997). "Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway". EMBO J 15 (17): 4537–46. PMC 452183. PMID 8887545.
2. Osada S, Izawa M, Saito R, Mizuno K, Suzuki A, Hirai S, Ohno S (Jun 1997). "YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways". Oncogene 14 (17): 2047–57. doi:10.1038/sj.onc.1201043. PMID 9160885.
3. Preisinger C, Short B, De Corte V, Bruyneel E, Haas A, Kopajtich R, Gettemans J, Barr FA (Mar 2004). "YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta". J Cell Biol 164 (7): 1009–20. doi:10.1083/jcb.200310061. PMC 2172068. PMID 15037601.
4. "Entrez Gene: STK25 serine/threonine kinase 25 (STE20 homolog, yeast)".
5. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (January 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
6. Rual JF, Venkatesan K, Hao T, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Findlay GM, Yan L, Procter J, et al. (2007). "A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling.". Biochem. J. 403 (1): 13–20. doi:10.1042/BJ20061881. PMC 1828895. PMID 17253963.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Matsuki T, Matthews RT, Cooper JA, van der Brug MP, Cookson MR, Hardy JA, Olson EC, Howell BW (November 2010). "Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment". Cell 143 (5): 826–36. doi:10.1016/j.cell.2010.10.029. PMC 3033572. PMID 21111240.