RPS13

Ribosomal protein S13
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4V6X​, 5AJ0​
Identifiers
Symbols	RPS13 ; S13
External IDs	OMIM: 180476 MGI: 1915302 HomoloGene: 128182 GeneCards: RPS13 Gene
EC number	3.6.5.3
Gene ontology Molecular function • mRNA binding • structural constituent of ribosome • protein binding • poly(A) RNA binding • small ribosomal subunit rRNA binding Cellular component • nucleus • nucleolus • cytosol • ribosome • focal adhesion • membrane • cytosolic small ribosomal subunit • extracellular exosome Biological process • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • translation • translational initiation • translational elongation • translational termination • SRP-dependent cotranslational protein targeting to membrane • gene expression • viral process • viral life cycle • viral transcription • negative regulation of RNA splicing • cellular protein metabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6207	68052
Ensembl	ENSG00000110700	ENSMUSG00000090862
UniProt	P62277	P62301
RefSeq (mRNA)	NM_001017	NM_026533
RefSeq (protein)	NP_001008	NP_080809
Location (UCSC)	Chr 11: 17.07 – 17.08 Mb	Chr 7: 116.33 – 116.33 Mb
PubMed search

40S ribosomal protein S13 is a protein that in humans is encoded by the RPS13 gene.^[1][2][3]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[3]

Interactions

RPS13 has been shown to interact with PDCD4.^[4]

References

1. Chadeneau C, LeMoullac B, Denis MG (Aug 1993). "Cloning and analysis of the human S13 ribosomal protein cDNA". Nucleic Acids Res 21 (12): 2945. doi:10.1093/nar/21.12.2945. PMC 309694. PMID 8332508.
2. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
3. "Entrez Gene: RPS13 ribosomal protein S13".
4. Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY (April 2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochem. Biophys. Res. Commun. 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11-12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Suzuki K, Olvera J, Wool IG (1990). "The primary structure of rat ribosomal protein S13.". Biochem. Biophys. Res. Commun. 171 (2): 519–24. doi:10.1016/0006-291X(90)91176-S. PMID 2403345.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
• Kenmochi N, Higa S, Yoshihama M, Tanaka T (1996). "U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene.". Biochem. Biophys. Res. Commun. 228 (2): 371–4. doi:10.1006/bbrc.1996.1668. PMID 8920921.
• Caldwell GM, Eddy RL, Day CD, et al. (2001). "Mapping of genes and transcribed sequences in a gene rich 400-kb region on human chromosome 11p15.1→p14.". Cytogenet. Cell Genet. 92 (1-2): 103–7. doi:10.1159/000056877. PMID 11306805.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Kang MJ, Ahn HS, Lee JY, et al. (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts.". Biochem. Biophys. Res. Commun. 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lundgren J, Masson P, Realini CA, Young P (2003). "Use of RNA interference and complementation to study the function of the Drosophila and human 26S proteasome subunit S13.". Mol. Cell. Biol. 23 (15): 5320–30. doi:10.1128/MCB.23.15.5320-5330.2003. PMC 165711. PMID 12861018.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Shi Y, Zhai H, Wang X, et al. (2004). "Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis.". Exp. Cell Res. 296 (2): 337–46. doi:10.1016/j.yexcr.2004.02.009. PMID 15149863.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Malygin A, Parakhnevitch N, Karpova G (2005). "Human ribosomal protein S13: cloning, expression, refolding, and structural stability.". Biochim. Biophys. Acta 1747 (1): 93–7. doi:10.1016/j.bbapap.2004.10.001. PMID 15680243.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes.". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.