RuvB-like 1

RuvB-like AAA ATPase 1

PDB rendering based on 2c9o.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RUVBL1 ; ECP54; INO80H; NMP238; PONTIN; Pontin52; RVB1; TIH1; TIP49; TIP49A
External IDs OMIM: 603449 MGI: 1928760 HomoloGene: 37839 GeneCards: RUVBL1 Gene
EC number 3.6.4.12
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 8607 56505
Ensembl ENSG00000175792 ENSMUSG00000030079
UniProt Q9Y265 P60122
RefSeq (mRNA) NM_003707 NM_019685
RefSeq (protein) NP_003698 NP_062659
Location (UCSC) Chr 3:
128.06 – 128.15 Mb
Chr 6:
88.47 – 88.5 Mb
PubMed search

RuvB-like 1 (E. coli), also known as RUVBL1 and TIP49, is a human gene.[1] RUVBL1 can form a hexamer. The hexamer can form a dodecamer with RUVBL2 protein.[2] Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.

Interactions

RuvB-like 1 has been shown to interact with:

References

  1. "Entrez Gene: RUVBL1 RuvB-like 1 (E. coli)".
  2. Puri T, Wendler P, Sigala B, Saibil H, Tsaneva IR (February 2007). "Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex". J. Mol. Biol. 366 (1): 179–92. doi:10.1016/j.jmb.2006.11.030. PMID 17157868.
  3. 1 2 Park J, Wood MA, Cole MD (March 2002). "BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation". Mol. Cell. Biol. 22 (5): 1307–16. doi:10.1128/mcb.22.5.1307-1316.2002. PMC 134713. PMID 11839798.
  4. Bauer A, Huber O, Kemler R (Dec 1998). "Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein". Proc. Natl. Acad. Sci. U.S.A. 95 (25): 14787–92. doi:10.1073/pnas.95.25.14787. PMC 24527. PMID 9843967.
  5. 1 2 Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM (August 2001). "The p400 complex is an essential E1A transformation target". Cell 106 (3): 297–307. doi:10.1016/s0092-8674(01)00450-0. PMID 11509179.
  6. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading


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