Retinal isomerase

In enzymology, a retinal isomerase (EC 5.2.1.3) is an enzyme that catalyzes the isomerisation of trans Retinal in eye into 11-cis-retinal which is form suitable to bind with protein opsin

all-trans-retinal

\rightleftharpoons

11-cis-retinal

Hence, this enzyme has one substrate, all-trans-retinal, and one product, 11-cis-retinal.

This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. The systematic name of this enzyme class is all-trans-retinal 11-cis-trans-isomerase. Other names in common use include retinene isomerase, and retinoid isomerase. This enzyme participates in retinol metabolism.

References

HUBBARD R (1956). "Retinene isomerase". J. Gen. Physiol. 39 (6): 935–62. doi:10.1085/jgp.39.6.935. PMC 2147571. PMID 13346046.
Shichi H, Somers RL (1974). "Possible involvement of retinylidene phospholipid in photoisomerization of all-trans-retinal to 11-cis-retinal". J. Biol. Chem. 249 (20): 6570–7. PMID 4472816.

Isomerases: geometric (EC 5.2)

5.2.1	FKBP: FKBP1A FKBP1B FKBP2 FKBP3 FKBP5 FKBP6 FKBP8 FKBP9 FKBP10 FKBP52 FKBPL other: Cyclophilin Parvulin Prolyl isomerase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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