Rubredoxin—NAD(P)(+) reductase

rubredoxin—NAD(P)+ reductase
Identifiers
EC number	1.18.1.4
CAS number	114514-31-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a rubredoxin—NAD(P)+ reductase (EC 1.18.1.4) is an enzyme that catalyzes the chemical reaction

reduced rubredoxin + NAD(P)+ $\rightleftharpoons$ oxidized rubredoxin + NAD(P)H + H⁺

The 3 substrates of this enzyme are reduced rubredoxin, NAD⁺, and NADP⁺, whereas its 4 products are oxidized rubredoxin, NADH, NADPH, and H⁺.^[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on iron-sulfur proteins as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is rubredoxin:NAD(P)+ oxidoreductase. Other names in common use include rubredoxin-nicotinamide adenine dinucleotide (phosphate) reductase, rubredoxin-nicotinamide adenine, dinucleotide phosphate reductase, NAD(P)+-rubredoxin oxidoreductase, and NAD(P)H-rubredoxin oxidoreductase. This enzyme participates in fatty acid metabolism.

References

1. Petitdemange, H., Blusson, H. and Gay, R. (1981). "Detection of NAD(P)H-rubredoxin oxidoreductases in Clostridia". Anal. Biochem. 116: 564–570. doi:10.1016/0003-2697(81)90403-6. PMID 6274224.
2. Ma, K. and Adams, M.W.W. (1999). "A hyperactive NAD(P)H:rubredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus". J. Bacteriol. 181 (17): 5530–5533. PMC 94068. PMID 10464233.

External links

• Rubredoxin---NAD(P) reductase at the US National Library of Medicine Medical Subject Headings (MeSH)