S-adenosylhomocysteine deaminase

S-adenosylhomocysteine deaminase
Identifiers
EC number	3.5.4.28
CAS number	125149-24-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a S-adenosylhomocysteine deaminase (EC 3.5.4.28) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-homocysteine + H₂O $\rightleftharpoons$ S-inosyl-L-homocysteine + NH₃

Thus, the two substrates of this enzyme are S-adenosyl-L-homocysteine and H₂O, whereas its two products are S-inosyl-L-homocysteine and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is S-adenosyl-L-homocysteine aminohydrolase. This enzyme is also called adenosylhomocysteine deaminase.

References

• Zulty JJ, Speedie MK (1989). "Purification and characterization of S-adenosylhomocysteine deaminase from streptonigrin-producing Streptomyces flocculus". J. Bacteriol. 171 (12): 6840–4. PMC 210584. PMID 2592350.