Protein SET

SET nuclear proto-oncogene
PDB rendering based on 2e50.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2E50​
Identifiers
Symbols	SET ; 2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII; TAF-I; TAF-IBETA
External IDs	OMIM: 600960 MGI: 1860267 HomoloGene: 55707 GeneCards: SET Gene
Gene ontology Molecular function • DNA binding • protein phosphatase inhibitor activity • protein binding • protein phosphatase type 2A regulator activity • histone binding Cellular component • nucleus • nucleoplasm • cytoplasm • endoplasmic reticulum • cytosol • protein complex • perinuclear region of cytoplasm Biological process • mitotic cell cycle • DNA replication • nucleosome assembly • nucleosome disassembly • nucleocytoplasmic transport • gene expression • viral process • regulation of protein phosphatase type 2A activity • negative regulation of histone acetylation • negative regulation of catalytic activity • negative regulation of neuron apoptotic process • negative regulation of transcription, DNA-templated Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6418	56086
Ensembl	ENSG00000119335	ENSMUSG00000054766
UniProt	Q01105	Q9EQU5
RefSeq (mRNA)	NM_001122821	NM_001204875
RefSeq (protein)	NP_001116293	NP_001191804
Location (UCSC)	Chr 9: 128.68 – 128.7 Mb	Chr 2: 30.06 – 30.07 Mb
PubMed search

Protein SET is a protein that in humans is encoded by the SET gene.^[1][2][3]

Interactions

Protein SET has been shown to interact with:

• Acidic leucine-rich nuclear phosphoprotein 32 family member A,^[4][5]
• CDK5R1,^[6]
• KLF5,^[7]
• NME1,^[8] and
• TAF1A.^[4]

References

1. von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G (Aug 1992). "Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene". Molecular and Cellular Biology 12 (8): 3346–55. doi:10.1128/mcb.12.8.3346. PMC 364582. PMID 1630450.
2. Li M, Makkinje A, Damuni Z (May 1996). "The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A". The Journal of Biological Chemistry 271 (19): 11059–62. doi:10.1074/jbc.271.19.11059. PMID 8626647.
3. "Entrez Gene: SET SET translocation (myeloid leukemia-associated)".
4. Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (Jan 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell 104 (1): 119–30. doi:10.1016/s0092-8674(01)00196-9. PMID 11163245.
5. Fan Z, Beresford PJ, Zhang D, Lieberman J (Apr 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Molecular and Cellular Biology 22 (8): 2810–20. doi:10.1128/mcb.22.8.2810-2820.2002. PMC 133744. PMID 11909973.
6. Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". The Journal of Biological Chemistry 277 (9): 7324–32. doi:10.1074/jbc.M107270200. PMID 11741927.
7. Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology 23 (23): 8528–41. doi:10.1128/mcb.23.23.8528-8541.2003. PMC 262669. PMID 14612398.
8. Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J (Mar 2003). "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor". Cell 112 (5): 659–72. doi:10.1016/s0092-8674(03)00150-8. PMID 12628186.

Further reading

• Nagata K, Kawase H, Handa H, Yano K, Yamasaki M, Ishimi Y, Okuda A, Kikuchi A, Matsumoto K (May 1995). "Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis". Proceedings of the National Academy of Sciences of the United States of America 92 (10): 4279–83. doi:10.1073/pnas.92.10.4279. PMC 41927. PMID 7753797.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Adachi Y, Pavlakis GN, Copeland TD (Mar 1994). "Identification of in vivo phosphorylation sites of SET, a nuclear phosphoprotein encoded by the translocation breakpoint in acute undifferentiated leukemia". FEBS Letters 340 (3): 231–5. doi:10.1016/0014-5793(94)80144-4. PMID 8131851.
• Vaesen M, Barnikol-Watanabe S, Götz H, Awni LA, Cole T, Zimmermann B, Kratzin HD, Hilschmann N (Feb 1994). "Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII". Biological Chemistry Hoppe-Seyler 375 (2): 113–26. doi:10.1515/bchm3.1994.375.2.113. PMID 8192856.
• Adachi Y, Pavlakis GN, Copeland TD (Jan 1994). "Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia". The Journal of Biological Chemistry 269 (3): 2258–62. PMID 8294483.
• Adler HT, Nallaseth FS, Walter G, Tkachuk DC (Nov 1997). "HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A". The Journal of Biological Chemistry 272 (45): 28407–14. doi:10.1074/jbc.272.45.28407. PMID 9353299.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Carlson SG, Eng E, Kim EG, Perlman EJ, Copeland TD, Ballermann BJ (Oct 1998). "Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor". Journal of the American Society of Nephrology 9 (10): 1873–80. PMID 9773788.
• Brennan CM, Gallouzi IE, Steitz JA (Oct 2000). "Protein ligands to HuR modulate its interaction with target mRNAs in vivo". The Journal of Cell Biology 151 (1): 1–14. doi:10.1083/jcb.151.1.1. PMC 2189805. PMID 11018049.
• Shikama N, Chan HM, Krstic-Demonacos M, Smith L, Lee CW, Cairns W, La Thangue NB (Dec 2000). "Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators". Molecular and Cellular Biology 20 (23): 8933–43. doi:10.1128/MCB.20.23.8933-8943.2000. PMC 86548. PMID 11073993.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (Jan 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. PMID 11163245.
• Minakuchi M, Kakazu N, Gorrin-Rivas MJ, Abe T, Copeland TD, Ueda K, Adachi Y (Mar 2001). "Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET". European Journal of Biochemistry / FEBS 268 (5): 1340–51. doi:10.1046/j.1432-1327.2001.02000.x. PMID 11231286.
• Beresford PJ, Zhang D, Oh DY, Fan Z, Greer EL, Russo ML, Jaju M, Lieberman J (Nov 2001). "Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks". The Journal of Biological Chemistry 276 (46): 43285–93. doi:10.1074/jbc.M108137200. PMID 11555662.
• Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". The Journal of Biological Chemistry 277 (9): 7324–32. doi:10.1074/jbc.M107270200. PMID 11741927.
• Fan Z, Beresford PJ, Zhang D, Lieberman J (Apr 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Molecular and Cellular Biology 22 (8): 2810–20. doi:10.1128/MCB.22.8.2810-2820.2002. PMC 133744. PMID 11909973.
• Cervoni N, Detich N, Seo SB, Chakravarti D, Szyf M (Jul 2002). "The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing". The Journal of Biological Chemistry 277 (28): 25026–31. doi:10.1074/jbc.M202256200. PMID 11978794.