SFPQ

Splicing factor proline/glutamine-rich
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4WII​, 4WIJ​, 4WIK​
Identifiers
Symbols	SFPQ ; POMP100; PPP1R140; PSF
External IDs	OMIM: 605199 MGI: 1918764 HomoloGene: 3714 GeneCards: SFPQ Gene
Gene ontology Molecular function • nucleotide binding • transcription regulatory region sequence-specific DNA binding • RNA polymerase II distal enhancer sequence-specific DNA binding • core promoter binding • chromatin binding • protein binding • histone deacetylase binding • transcription regulatory region DNA binding • poly(A) RNA binding Cellular component • chromatin • nucleus • nucleoplasm • cytoplasm • nuclear matrix • paraspeckles • RNA polymerase II transcription factor complex Biological process • negative regulation of transcription from RNA polymerase II promoter • alternative mRNA splicing, via spliceosome • double-strand break repair via homologous recombination • transcription, DNA-templated • mRNA processing • RNA splicing • regulation of circadian rhythm • negative regulation of circadian rhythm • positive regulation of sister chromatid cohesion • negative regulation of transcription, DNA-templated • rhythmic process • histone H3 deacetylation • positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6421	71514
Ensembl	ENSG00000116560	ENSMUSG00000028820
UniProt	P23246	Q8VIJ6
RefSeq (mRNA)	NM_005066	NM_023603
RefSeq (protein)	NP_005057	NP_076092
Location (UCSC)	Chr 1: 35.18 – 35.19 Mb	Chr 4: 127.02 – 127.04 Mb
PubMed search

Splicing factor, proline- and glutamine-rich is a protein that in humans is encoded by the SFPQ gene.^[1][2]

Interactions

SFPQ has been shown to interact with PTBP1,^[1][3] NONO,^[4] CDC5L^[5] and Ubiquitin C.^[6]

References

1. Patton JG, Porro EB, Galceran J, Tempst P, Nadal-Ginard B (Mar 1993). "Cloning and characterization of PSF, a novel pre-mRNA splicing factor". Genes & Development 7 (3): 393–406. doi:10.1101/gad.7.3.393. PMID 8449401.
2. "Entrez Gene: SFPQ splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)".
3. Meissner M, Dechat T, Gerner C, Grimm R, Foisner R, Sauermann G (Jan 2000). "Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB". Journal of Cellular Biochemistry 76 (4): 559–66. doi:10.1002/(SICI)1097-4644(20000315)76:4<559::AID-JCB4>3.0.CO;2-U. PMID 10653975.
4. Peng R, Dye BT, Pérez I, Barnard DC, Thompson AB, Patton JG (Oct 2002). "PSF and p54nrb bind a conserved stem in U5 snRNA". Rna 8 (10): 1334–47. doi:10.1017/S1355838202022070. PMC 1370341. PMID 12403470.
5. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
6. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.

Further reading

• Shav-Tal Y, Zipori D (Nov 2002). "PSF and p54(nrb)/NonO--multi-functional nuclear proteins". FEBS Letters 531 (2): 109–14. doi:10.1016/S0014-5793(02)03447-6. PMID 12417296.
• Gower HJ, Moore SE, Dickson G, Elsom VL, Nayak R, Walsh FS (Apr 1989). "Cloning and characterization of a myoblast cell surface antigen defined by 24.1D5 monoclonal antibody". Development 105 (4): 723–31. PMID 2480877.
• Gozani O, Patton JG, Reed R (Jul 1994). "A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction". The EMBO Journal 13 (14): 3356–67. PMC 395233. PMID 8045264.
• Zhang WW, Zhang LX, Busch RK, Farrés J, Busch H (Feb 1993). "Purification and characterization of a DNA-binding heterodimer of 52 and 100 kDa from HeLa cells". The Biochemical Journal. 290 ( Pt 1) (1): 267–72. PMC 1132410. PMID 8439294.
• Clark J, Lu YJ, Sidhar SK, Parker C, Gill S, Smedley D, Hamoudi R, Linehan WM, Shipley J, Cooper CS (Oct 1997). "Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma". Oncogene 15 (18): 2233–9. doi:10.1038/sj.onc.1201394. PMID 9393982.
• Teigelkamp S, Mundt C, Achsel T, Will CL, Lührmann R (Nov 1997). "The human U5 snRNP-specific 100-kD protein is an RS domain-containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p". Rna 3 (11): 1313–26. PMC 1369570. PMID 9409622.
• Straub T, Grue P, Uhse A, Lisby M, Knudsen BR, Tange TO, Westergaard O, Boege F (Oct 1998). "The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction". The Journal of Biological Chemistry 273 (41): 26261–4. doi:10.1074/jbc.273.41.26261. PMID 9756848.
• Lutz CS, Cooke C, O'Connor JP, Kobayashi R, Alwine JC (Dec 1998). "The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor". Rna 4 (12): 1493–9. doi:10.1017/S1355838298981183. PMC 1369720. PMID 9848648.
• Meissner M, Dechat T, Gerner C, Grimm R, Foisner R, Sauermann G (Jan 2000). "Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB". Journal of Cellular Biochemistry 76 (4): 559–66. doi:10.1002/(SICI)1097-4644(20000315)76:4<559::AID-JCB4>3.0.CO;2-U. PMID 10653975.
• Urban RJ, Bodenburg Y, Kurosky A, Wood TG, Gasic S (Jun 2000). "Polypyrimidine tract-binding protein-associated splicing factor is a negative regulator of transcriptional activity of the porcine p450scc insulin-like growth factor response element". Molecular Endocrinology 14 (6): 774–82. doi:10.1210/me.14.6.774. PMID 10847580.
• Straub T, Knudsen BR, Boege F (Jun 2000). "PSF/p54(nrb) stimulates "jumping" of DNA topoisomerase I between separate DNA helices". Biochemistry 39 (25): 7552–8. doi:10.1021/bi992898e. PMID 10858305.
• Akhmedov AT, Lopez BS (Aug 2000). "Human 100-kDa homologous DNA-pairing protein is the splicing factor PSF and promotes DNA strand invasion". Nucleic Acids Research 28 (16): 3022–30. doi:10.1093/nar/28.16.3022. PMC 108454. PMID 10931916.
• de Vries H, Rüegsegger U, Hübner W, Friedlein A, Langen H, Keller W (Nov 2000). "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors". The EMBO Journal 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMC 305781. PMID 11060040.
• Dye BT, Patton JG (Feb 2001). "An RNA recognition motif (RRM) is required for the localization of PTB-associated splicing factor (PSF) to subnuclear speckles". Experimental Cell Research 263 (1): 131–44. doi:10.1006/excr.2000.5097. PMID 11161712.
• Mathur M, Tucker PW, Samuels HH (Apr 2001). "PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors". Molecular and Cellular Biology 21 (7): 2298–311. doi:10.1128/MCB.21.7.2298-2311.2001. PMC 86864. PMID 11259580.
• Shav-Tal Y, Cohen M, Lapter S, Dye B, Patton JG, Vandekerckhove J, Zipori D (Aug 2001). "Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions". Molecular Biology of the Cell 12 (8): 2328–40. doi:10.1091/mbc.12.8.2328. PMC 58597. PMID 11514619.
• Zhang Z, Carmichael GG (Aug 2001). "The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs". Cell 106 (4): 465–75. doi:10.1016/S0092-8674(01)00466-4. PMID 11525732.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (Jan 2002). "Directed proteomic analysis of the human nucleolus". Current Biology 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Sewer MB, Nguyen VQ, Huang CJ, Tucker PW, Kagawa N, Waterman MR (Apr 2002). "Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription". Endocrinology 143 (4): 1280–90. doi:10.1210/en.143.4.1280. PMID 11897684.