SHB (gene)

Src homology 2 domain containing adaptor protein B
Identifiers
Symbols SHB ; bA3J10.2
External IDs OMIM: 600314 MGI: 98294 HomoloGene: 74458 GeneCards: SHB Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 6461 230126
Ensembl ENSG00000107338 ENSMUSG00000044813
UniProt Q15464 Q6PD21
RefSeq (mRNA) NM_003028 NM_001033306
RefSeq (protein) NP_003019 NP_001028478
Location (UCSC) Chr 9:
37.92 – 38.07 Mb		 Chr 4:
45.42 – 45.53 Mb
PubMed search

SH2 domain-containing adapter protein B is a protein that in humans is encoded by the SHB gene.[1][2]


Interactions

SHB (gene) has been shown to interact with:

References

  1. ↑ Yulug IG, Hillermann R, Fisher EM (Dec 1994). "The SHB adaptor protein maps to human chromosome 9". Genomics 24 (3): 615–7. doi:10.1006/geno.1994.1681. PMID 7713524.
  2. ↑ "Entrez Gene: SHB Src homology 2 domain containing adaptor protein B".
  3. 1 2 3 4 Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M (Apr 1995). "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene 10 (8): 1475–83. PMID 7537362.
  4. ↑ Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M (Sep 1999). "Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells". The Journal of Biological Chemistry 274 (39): 28050–7. doi:10.1074/jbc.274.39.28050. PMID 10488157.
  5. 1 2 3 4 Lindholm CK, Henriksson ML, Hallberg B, Welsh M (Jul 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells". European Journal of Biochemistry / FEBS 269 (13): 3279–88. doi:10.1046/j.1432-1033.2002.03008.x. PMID 12084069.

Further reading

  • Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M (Apr 1995). "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene 10 (8): 1475–83. PMID 7537362. 
  • Welsh M, Mares J, Karlsson T, Lavergne C, Bréant B, Claesson-Welsh L (Jan 1994). "Shb is a ubiquitously expressed Src homology 2 protein". Oncogene 9 (1): 19–27. PMID 8302579. 
  • Karlsson T, Welsh M (Sep 1996). "Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb". Oncogene 13 (5): 955–61. PMID 8806685. 
  • Welsh M, Songyang Z, Frantz JD, Trüb T, Reedquist KA, Karlsson T, Miyazaki M, Cantley LC, Band H, Shoelson SE (Feb 1998). "Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins". Oncogene 16 (7): 891–901. doi:10.1038/sj.onc.1201607. PMID 9484780. 
  • Karlsson T, Kullander K, Welsh M (Sep 1998). "The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells". Cell Growth & Differentiation 9 (9): 757–66. PMID 9751119. 
  • Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M (Sep 1999). "Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells". The Journal of Biological Chemistry 274 (39): 28050–7. doi:10.1074/jbc.274.39.28050. PMID 10488157. 
  • Dixelius J, Larsson H, Sasaki T, Holmqvist K, Lu L, Engström A, Timpl R, Welsh M, Claesson-Welsh L (Jun 2000). "Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis". Blood 95 (11): 3403–11. PMID 10828022. 
  • Hooshmand-Rad R, Lu L, Heldin CH, Claesson-Welsh L, Welsh M (Jun 2000). "Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization". Experimental Cell Research 257 (2): 245–54. doi:10.1006/excr.2000.4896. PMID 10837138. 
  • Lu L, Annerén C, Reedquist KA, Bos JL, Welsh M (Sep 2000). "NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway". Experimental Cell Research 259 (2): 370–7. doi:10.1006/excr.2000.4984. PMID 10964504. 
  • Diakonova M, Gunter DR, Herrington J, Carter-Su C (Mar 2002). "SH2-Bbeta is a Rac-binding protein that regulates cell motility". The Journal of Biological Chemistry 277 (12): 10669–77. doi:10.1074/jbc.M111138200. PMID 11786545. 
  • Lindholm CK, Henriksson ML, Hallberg B, Welsh M (Jul 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells". European Journal of Biochemistry / FEBS 269 (13): 3279–88. doi:10.1046/j.1432-1033.2002.03008.x. PMID 12084069. 
  • Cross MJ, Lu L, Magnusson P, Nyqvist D, Holmqvist K, Welsh M, Claesson-Welsh L (Aug 2002). "The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells". Molecular Biology of the Cell 13 (8): 2881–93. doi:10.1091/mbc.E02-02-0103. PMC 117949. PMID 12181353. 
  • Lindholm CK (Aug 2002). "IL-2 receptor signaling through the Shb adapter protein in T and NK cells". Biochemical and Biophysical Research Communications 296 (4): 929–36. doi:10.1016/S0006-291X(02)02016-8. PMID 12200137. 
  • Holmqvist K, Cross M, Riley D, Welsh M (Feb 2003). "The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells". Cellular Signalling 15 (2): 171–9. doi:10.1016/S0898-6568(02)00076-1. PMID 12464388. 
  • Welsh N, Makeeva N, Welsh M (Nov 2002). "Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins". Molecular Medicine 8 (11): 695–704. PMC 2039954. PMID 12520086. 
  • Holmqvist K, Cross MJ, Rolny C, Hägerkvist R, Rahimi N, Matsumoto T, Claesson-Welsh L, Welsh M (May 2004). "The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration". The Journal of Biological Chemistry 279 (21): 22267–75. doi:10.1074/jbc.M312729200. PMID 15026417. 
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