SNAPC3

Small nuclear RNA activating complex, polypeptide 3, 50kDa
Identifiers
Symbols	SNAPC3 ; PTFbeta; SNAP50
External IDs	OMIM: 602348 MGI: 1916338 HomoloGene: 31130 GeneCards: SNAPC3 Gene
Gene ontology Molecular function • DNA binding • protein binding Cellular component • nucleus • nucleoplasm • nucleolus Biological process • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • transcription from RNA polymerase III promoter • snRNA transcription • gene expression Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6619	77634
Ensembl	ENSG00000164975	ENSMUSG00000028483
UniProt	Q92966	Q9D2C9
RefSeq (mRNA)	NM_001039697	NM_029949
RefSeq (protein)	NP_001034786	NP_084225
Location (UCSC)	Chr 9: 15.42 – 15.47 Mb	Chr 4: 83.42 – 83.47 Mb
PubMed search

snRNA-activating protein complex subunit 3 is a protein that in humans is encoded by the SNAPC3 gene.^[1][2]

Interactions

SNAPC3 has been shown to interact with SNAPC1^[1][3] and Retinoblastoma protein.^[4]

References

1. Henry RW, Ma B, Sadowski CL, Kobayashi R, Hernandez N (February 1997). "Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc". EMBO J 15 (24): 7129–36. PMC 452539. PMID 9003788.
2. "Entrez Gene: SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa".
3. Ma, B; Hernandez N (February 2001). "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc". J. Biol. Chem. (United States) 276 (7): 5027–35. doi:10.1074/jbc.M009301200. ISSN 0021-9258. PMID 11056176.
4. Hirsch, H A; Gu L; Henry R W (Dec 2000). "The retinoblastoma tumor suppressor protein targets distinct general transcription factors to regulate RNA polymerase III gene expression". Mol. Cell. Biol. (UNITED STATES) 20 (24): 9182–91. doi:10.1128/MCB.20.24.9182-9191.2000. ISSN 0270-7306. PMC 102176. PMID 11094070.

Further reading

• Bagramian ER, Bogdanova EA, Krymskaia ML, Sokovykh SI (1977). "[Diagnostic importance of determining 17-ketosteroids in gynecology]". Akusherstvo i ginekologiia (2): 65–7. PMID 900378.
• Henry RW, Sadowski CL, Kobayashi R, Hernandez N (1995). "A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III.". Nature 374 (6523): 653–6. doi:10.1038/374653a0. PMID 7715707.
• Bai L, Wang Z, Yoon JB, Roeder RG (1996). "Cloning and characterization of the beta subunit of human proximal sequence element-binding transcription factor and its involvement in transcription of small nuclear RNA genes by RNA polymerases II and III.". Mol. Cell. Biol. 16 (10): 5419–26. PMC 231541. PMID 8816454.
• Ma B, Hernandez N (2001). "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc.". J. Biol. Chem. 276 (7): 5027–35. doi:10.1074/jbc.M009301200. PMID 11056176.
• Hirsch HA, Gu L, Henry RW (2001). "The retinoblastoma tumor suppressor protein targets distinct general transcription factors to regulate RNA polymerase III gene expression.". Mol. Cell. Biol. 20 (24): 9182–91. doi:10.1128/MCB.20.24.9182-9191.2000. PMC 102176. PMID 11094070.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hinkley CS, Hirsch HA, Gu L, et al. (2003). "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition.". J. Biol. Chem. 278 (20): 18649–57. doi:10.1074/jbc.M204247200. PMID 12621023.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Jawdekar GW, Hanzlowsky A, Hovde SL, et al. (2006). "The unorthodox SNAP50 zinc finger domain contributes to cooperative promoter recognition by human SNAPC.". J. Biol. Chem. 281 (41): 31050–60. doi:10.1074/jbc.M603810200. PMID 16901896.