Surfactant protein D

Surfactant protein D
PDB rendering based on 1b08.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1B08​, 1M7L​, 1PW9​, 1PWB​, 2GGU​, 2GGX​, 2ORJ​, 2ORK​, 2OS9​, 2RIA​, 2RIB​, 2RIC​, 2RID​, 2RIE​, 3DBZ​, 3G81​, 3G83​, 3G84​, 3IKN​, 3IKP​, 3IKQ​, 3IKR​, 4E52​, 4M17​, 4M18​
Identifiers
Symbols	SFTPD ; COLEC7; PSP-D; SFTP4; SP-D
External IDs	OMIM: 178635 MGI: 109515 HomoloGene: 2272 GeneCards: SFTPD Gene
Gene ontology Molecular function • protein binding • carbohydrate binding Cellular component • extracellular region • proteinaceous extracellular matrix • collagen trimer • extracellular space • lysosome • endocytic vesicle Biological process • regulation of cytokine production • receptor-mediated endocytosis • respiratory gaseous exchange • negative regulation of T cell proliferation • defense response to bacterium • surfactant homeostasis • negative regulation of interleukin-2 biosynthetic process • innate immune response • macrophage chemotaxis • lung alveolus development • positive regulation of phagocytosis • reactive oxygen species metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6441	20390
Ensembl	ENSG00000133661	ENSMUSG00000021795
UniProt	P35247	P50404
RefSeq (mRNA)	NM_003019	NM_009160
RefSeq (protein)	NP_003010	NP_033186
Location (UCSC)	Chr 10: 79.94 – 79.98 Mb	Chr 14: 41.17 – 41.19 Mb
PubMed search

Surfactant, pulmonary-associated protein D, also known as SFTPD or SP-D, is a protein which in humans is encoded by the SFTPD gene.^[1][2]

SFTPD is an innate immune system collectin.^[3][4]

Interactions

Surfactant protein D has been shown to interact with DMBT1,^[5][6] and hemagglutinin of influenza A virus.^[7]

See also

• pulmonary surfactant

References

1. Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, Cai GZ, Crouch E (October 1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Arch. Biochem. Biophys. 290 (1): 116–26. doi:10.1016/0003-9861(91)90597-C. PMID 1898081.
2. Lu J, Willis AC, Reid KB (June 1992). "Purification, characterization and cDNA cloning of human lung surfactant protein D". Biochem. J. 284. 284 ( Pt 3): 795–802. PMC 1132609. PMID 1339284.
3. "Entrez Gene: SFTPD surfactant, pulmonary-associated protein D".
4. Brandt EB, Mingler MK, Stevenson MD, Wang N, Khurana Hershey GK, Whitsett JA, Rothenberg ME (May 2008). "Surfactant protein D alters allergic lung responses in mice and human subjects". J. Allergy Clin. Immunol. 121 (5): 1140–1147.e2. doi:10.1016/j.jaci.2008.02.011. PMID 18355911.
5. Tino MJ, Wright JR (April 1999). "Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner". Am. J. Respir. Cell Mol. Biol. 20 (4): 759–68. doi:10.1165/ajrcmb.20.4.3439. PMID 10101009.
6. Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C, Koch C, Reid KB (May 1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule". J. Biol. Chem. 272 (21): 13743–9. doi:10.1074/jbc.272.21.13743. PMID 9153228.
7. Goh, Boon Chong; Rynkiewicz, Michael J.; Cafarella, Tanya R.; White, Mitchell R.; Hartshorn, Kevan L.; Allen, Kimberly; Crouch, Erika C.; Calin, Oliviana; Seeberger, Peter H. (2013-11-13). "Molecular Mechanisms of Inhibition of Influenza by Surfactant Protein D Revealed by Large-Scale Molecular Dynamics Simulation". Biochemistry 52 (47): 8527–8538. doi:10.1021/bi4010683. PMC 3927399. PMID 24224757.

External links

• Surfactant Protein D at the US National Library of Medicine Medical Subject Headings (MeSH)

Further reading

• Hansen S, Holmskov U (1998). "Structural aspects of collectins and receptors for collectins". Immunobiology 199 (2): 165–89. doi:10.1016/s0171-2985(98)80025-9. PMID 9777404.
• Lu J, Willis AC, Reid KB (1992). "Purification, characterization and cDNA cloning of human lung surfactant protein D". Biochem. J. 284. 284 ( Pt 3): 795–802. PMC 1132609. PMID 1339284.
• Ogasawara Y, Kuroki Y, Akino T (1992). "Pulmonary surfactant protein D specifically binds to phosphatidylinositol". J. Biol. Chem. 267 (29): 21244–9. PMID 1400434.
• Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, Cai GZ, Crouch E (1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Arch. Biochem. Biophys. 290 (1): 116–26. doi:10.1016/0003-9861(91)90597-C. PMID 1898081.
• Kuroki Y, Shiratori M, Ogasawara Y, Tsuzuki A, Akino T (1991). "Characterization of pulmonary surfactant protein D: its copurification with lipids". Biochim. Biophys. Acta 1086 (2): 185–90. doi:10.1016/0005-2760(91)90006-4. PMID 1932100.
• Crouch E, Persson A, Chang D, Heuser J (1994). "Molecular structure of pulmonary surfactant protein D (SP-D)". J. Biol. Chem. 269 (25): 17311–9. PMID 8006040.
• Schaeffer E, Guillou F, Part D, Zakin MM (1993). "A different combination of transcription factors modulates the expression of the human transferrin promoter in liver and Sertoli cells". J. Biol. Chem. 268 (31): 23399–408. PMID 8226864.
• Kölble K, Lu J, Mole SE, Kaluz S, Reid KB (1993). "Assignment of the human pulmonary surfactant protein D gene (SFTP4) to 10q22-q23 close to the surfactant protein A gene cluster". Genomics 17 (2): 294–8. doi:10.1006/geno.1993.1324. PMID 8406480.
• Crouch E, Persson A, Chang D (1993). "Accumulation of surfactant protein D in human pulmonary alveolar proteinosis". Am. J. Pathol. 142 (1): 241–8. PMC 1886847. PMID 8424457.
• Crouch E, Rust K, Veile R, Donis-Keller H, Grosso L (1993). "Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1". J. Biol. Chem. 268 (4): 2976–83. PMID 8428971.
• Rust K, Bingle L, Mariencheck W, Persson A, Crouch EC (1996). "Characterization of the human surfactant protein D promoter: transcriptional regulation of SP-D gene expression by glucocorticoids". Am. J. Respir. Cell Mol. Biol. 14 (2): 121–30. doi:10.1165/ajrcmb.14.2.8630261. PMID 8630261.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C, Koch C, Reid KB (1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule". J. Biol. Chem. 272 (21): 13743–9. doi:10.1074/jbc.272.21.13743. PMID 9153228.
• Botas C, Poulain F, Akiyama J, Brown C, Allen L, Goerke J, Clements J, Carlson E, Gillespie AM, Epstein C, Hawgood S (1998). "Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11869–74. doi:10.1073/pnas.95.20.11869. PMC 21732. PMID 9751757.
• Håkansson K, Lim NK, Hoppe HJ, Reid KB (1999). "Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D". Structure 7 (3): 255–64. doi:10.1016/S0969-2126(99)80036-7. PMID 10368295.
• Holmskov U, Mollenhauer J, Madsen J, Vitved L, Gronlund J, Tornoe I, Kliem A, Reid KB, Poustka A, Skjodt K (1999). "Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D". Proc. Natl. Acad. Sci. U.S.A. 96 (19): 10794–9. doi:10.1073/pnas.96.19.10794. PMC 17962. PMID 10485905.
• Lausen M, Lynch N, Schlosser A, Tornoe I, Saekmose SG, Teisner B, Willis AC, Crouch E, Schwaeble W, Holmskov U (1999). "Microfibril-associated protein 4 is present in lung washings and binds to the collagen region of lung surfactant protein D". J. Biol. Chem. 274 (45): 32234–40. doi:10.1074/jbc.274.45.32234. PMID 10542261.
• Madsen J, Kliem A, Tornoe I, Skjodt K, Koch C, Holmskov U (2000). "Localization of lung surfactant protein D on mucosal surfaces in human tissues". J. Immunol. 164 (11): 5866–70. doi:10.4049/jimmunol.164.11.5866. PMID 10820266.
• Zhang L, Ikegami M, Crouch EC, Korfhagen TR, Whitsett JA (2001). "Activity of pulmonary surfactant protein-D (SP-D) in vivo is dependent on oligomeric structure". J. Biol. Chem. 276 (22): 19214–9. doi:10.1074/jbc.M010191200. PMID 11278637.