STAB2

Stabilin 2
Identifiers
Symbols	STAB2 ; FEEL2; FELE-2; FELL2; FEX2; HARE
External IDs	OMIM: 608561 MGI: 2178743 HomoloGene: 23022 GeneCards: STAB2 Gene
Gene ontology Molecular function • low-density lipoprotein receptor activity • scavenger receptor activity • protein binding • hyaluronic acid binding • protein disulfide oxidoreductase activity • low-density lipoprotein particle binding Cellular component • cytoplasm • plasma membrane • integral component of plasma membrane • external side of plasma membrane • endocytic vesicle membrane Biological process • angiogenesis • carbohydrate metabolic process • endocytosis • receptor-mediated endocytosis • cell adhesion • regulation of gene expression • regulation of blood coagulation • glycosaminoglycan metabolic process • hyaluronan metabolic process • hyaluronan catabolic process • defense response to bacterium • small molecule metabolic process • oxidation-reduction process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55576	192188
Ensembl	ENSG00000136011	ENSMUSG00000035459
UniProt	Q8WWQ8	Q8R4U0
RefSeq (mRNA)	NM_017564	NM_138673
RefSeq (protein)	NP_060034	NP_619614
Location (UCSC)	Chr 12: 103.59 – 103.77 Mb	Chr 10: 86.84 – 87.01 Mb
PubMed search

Stabilin-2 is a protein that in humans is encoded by the STAB2 gene.^[1][2][3]

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes.^[3]

References

1. Politz O, Gratchev A, McCourt PA, Schledzewski K, Guillot P, Johansson S, Svineng G, Franke P, Kannicht C, Kzhyshkowska J, Longati P, Velten FW, Johansson S, Goerdt S (Feb 2002). "Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues". Biochem J 362 (Pt 1): 155–64. doi:10.1042/0264-6021:3620155. PMC 1222372. PMID 11829752.
2. Adachi H, Tsujimoto M (Sep 2002). "FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities". J Biol Chem 277 (37): 34264–70. doi:10.1074/jbc.M204277200. PMID 12077138.
3. "Entrez Gene: STAB2 stabilin 2".

Further reading

• Tamura Y, Adachi H, Osuga J, et al. (2003). "FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products". J. Biol. Chem. 278 (15): 12613–7. doi:10.1074/jbc.M210211200. PMID 12473645.
• Zhou B, McGary CT, Weigel JA, et al. (2004). "Purification and molecular identification of the human hyaluronan receptor for endocytosis". Glycobiology 13 (5): 339–49. doi:10.1093/glycob/cwg029. PMID 12626425.
• Smedsrød B, Johansson S, Goerdt S (2004). "Shooting HARE". Glycobiology 13 (5): 11G–12G; author reply 12G. doi:10.1093/glycob/cwg072. PMID 12751488.
• Dobreva G, Dambacher J, Grosschedl R (2004). "SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin μ gene expression". Genes Dev. 17 (24): 3048–61. doi:10.1101/gad.1153003. PMC 305257. PMID 14701874.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Harris EN, Weigel JA, Weigel PH (2004). "Endocytic function, glycosaminoglycan specificity, and antibody sensitivity of the recombinant human 190-kDa hyaluronan receptor for endocytosis (HARE)". J. Biol. Chem. 279 (35): 36201–9. doi:10.1074/jbc.M405322200. PMID 15208308.
• Hansen B, Longati P, Elvevold K, et al. (2005). "Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding". Exp. Cell Res. 303 (1): 160–73. doi:10.1016/j.yexcr.2004.09.017. PMID 15572036.
• Harris EN, Kyosseva SV, Weigel JA, Weigel PH (2007). "Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE)". J. Biol. Chem. 282 (5): 2785–97. doi:10.1074/jbc.M607787200. PMID 17145755.