STAG1

Stromal antigen 1
Identifiers
Symbols STAG1 ; SA1; SCC3A
External IDs OMIM: 604358 MGI: 1098658 HomoloGene: 21191 GeneCards: STAG1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 10274 20842
Ensembl ENSG00000118007 ENSMUSG00000037286
UniProt Q8WVM7 Q9D3E6
RefSeq (mRNA) NM_005862 NM_009282
RefSeq (protein) NP_005853 NP_033308
Location (UCSC) Chr 3:
136.34 – 136.75 Mb
Chr 9:
100.6 – 100.96 Mb
PubMed search

Cohesin subunit SA-1 is a protein that in humans is encoded by the STAG1 gene.[1][2]

This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase.[2]

Interactions

STAG1 has been shown to interact with STAG2.[3]

References

  1. Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, Prieto I, Carmi P, Gothelf Y, Gonzalez de Buitrago G, Aracil M, Marquez G, Barbero JL, Zipori D (October 1997). "SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs". Gene 195 (2): 151–9. doi:10.1016/S0378-1119(97)00121-2. PMID 9305759.
  2. 1 2 "Entrez Gene: STAG1 stromal antigen 1".
  3. Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. (UNITED STATES) 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443. PMID 11076961.

Further reading

External links


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