STAG1

Stromal antigen 1
Identifiers
Symbols	STAG1 ; SA1; SCC3A
External IDs	OMIM: 604358 MGI: 1098658 HomoloGene: 21191 GeneCards: STAG1 Gene
Gene ontology Molecular function • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • chromatin binding • protein binding Cellular component • chromosome, centromeric region • chromatin • nucleus • nucleoplasm • chromosome • cytosol Biological process • mitotic cell cycle • transcription from RNA polymerase II promoter • chromosome segregation • mitotic nuclear division • protein sumoylation • post-translational protein modification • cellular protein metabolic process • positive regulation of transcription from RNA polymerase II promoter • cell division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10274	20842
Ensembl	ENSG00000118007	ENSMUSG00000037286
UniProt	Q8WVM7	Q9D3E6
RefSeq (mRNA)	NM_005862	NM_009282
RefSeq (protein)	NP_005853	NP_033308
Location (UCSC)	Chr 3: 136.34 – 136.75 Mb	Chr 9: 100.6 – 100.96 Mb
PubMed search

Cohesin subunit SA-1 is a protein that in humans is encoded by the STAG1 gene.^[1][2]

This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase.^[2]

Interactions

STAG1 has been shown to interact with STAG2.^[3]

References

1. Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, Prieto I, Carmi P, Gothelf Y, Gonzalez de Buitrago G, Aracil M, Marquez G, Barbero JL, Zipori D (October 1997). "SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs". Gene 195 (2): 151–9. doi:10.1016/S0378-1119(97)00121-2. PMID 9305759.
2. "Entrez Gene: STAG1 stromal antigen 1".
3. Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. (UNITED STATES) 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443. PMID 11076961.

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Losada A, Yokochi T, Hirano T (2006). "Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts.". J. Cell. Sci. 118 (Pt 10): 2133–41. doi:10.1242/jcs.02355. PMID 15855230.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Anazawa Y, Arakawa H, Nakagawa H, Nakamura Y (2004). "Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway.". Oncogene 23 (46): 7621–7. doi:10.1038/sj.onc.1207270. PMID 15361841.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Prieto I, Pezzi N, Buesa JM, et al. (2003). "STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis.". EMBO Rep. 3 (6): 543–50. doi:10.1093/embo-reports/kvf108. PMC 1084142. PMID 12034751.
• Gregson HC, Schmiesing JA, Kim JS, et al. (2002). "A potential role for human cohesin in mitotic spindle aster assembly.". J. Biol. Chem. 276 (50): 47575–82. doi:10.1074/jbc.M103364200. PMID 11590136.
• Sumara I, Vorlaufer E, Gieffers C, et al. (2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase.". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.

External links

• STAG1 human gene location in the UCSC Genome Browser.
• STAG1 human gene details in the UCSC Genome Browser.