STAG2

Stromal antigen 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4PJU​, 4PJW​, 4PK7​
Identifiers
Symbols	STAG2 ; SA-2; SA2; SCC3B; bA517O1.1
External IDs	OMIM: 300826 MGI: 1098583 HomoloGene: 38206 GeneCards: STAG2 Gene
Gene ontology Molecular function • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • chromatin binding • protein binding Cellular component • chromosome, centromeric region • chromatin • nucleus • nucleoplasm • chromosome • nucleolus • cytosol • plasma membrane • actin cytoskeleton • membrane • intermediate filament cytoskeleton Biological process • mitotic cell cycle • transcription from RNA polymerase II promoter • sister chromatid cohesion • mitotic nuclear division • protein sumoylation • stem cell maintenance • negative regulation of DNA endoreduplication • post-translational protein modification • cellular protein metabolic process • positive regulation of transcription from RNA polymerase II promoter • cell division • meiotic cell cycle Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10735	20843
Ensembl	ENSG00000101972	ENSMUSG00000025862
UniProt	Q8N3U4	O35638
RefSeq (mRNA)	NM_001042749	NM_001077712
RefSeq (protein)	NP_001036214	NP_001071180
Location (UCSC)	Chr X: 123.96 – 124.42 Mb	Chr X: 42.15 – 42.28 Mb
PubMed search

Cohesin subunit SA-2 is a protein that in humans is encoded by the STAG2 gene.^[1][2]

Interactions

STAG2 has been shown to interact with STAG1.^[3]

References

1. Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, Prieto I, Carmi P, Gothelf Y, Gonzalez de Buitrago G, Aracil M, Marquez G, Barbero JL, Zipori D (October 1997). "SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs". Gene 195 (2): 151–9. doi:10.1016/S0378-1119(97)00121-2. PMID 9305759.
2. "Entrez Gene: STAG2 stromal antigen 2".
3. Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase". J. Cell Biol. (UNITED STATES) 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443. PMID 11076961.

Further reading

• Wu C, Friedlander P, Lamoureux C, et al. (1993). "cDNA clones contain autonomous replication activity". Biochim. Biophys. Acta 1174 (3): 241–57. doi:10.1016/0167-4781(93)90193-h. PMID 7690594.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Sumara I, Vorlaufer E, Gieffers C, et al. (2000). "Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.
• Gregson HC, Schmiesing JA, Kim JS, et al. (2002). "A potential role for human cohesin in mitotic spindle aster assembly". J. Biol. Chem. 276 (50): 47575–82. doi:10.1074/jbc.M103364200. PMID 11590136.
• Prieto I, Pezzi N, Buesa JM, et al. (2003). "STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis". EMBO Rep. 3 (6): 543–50. doi:10.1093/embo-reports/kvf108. PMC 1084142. PMID 12034751.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lara-Pezzi E, Pezzi N, Prieto I, et al. (2004). "Evidence of a transcriptional co-activator function of cohesin STAG/SA/Scc3". J. Biol. Chem. 279 (8): 6553–9. doi:10.1074/jbc.M307663200. PMID 14660624.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hauf S, Roitinger E, Koch B, et al. (2006). "Dissociation of Cohesin from Chromosome Arms and Loss of Arm Cohesion during Early Mitosis Depends on Phosphorylation of SA2". PLoS Biol. 3 (3): e69. doi:10.1371/journal.pbio.0030069. PMC 1054881. PMID 15737063.
• McGuinness BE, Hirota T, Kudo NR, et al. (2006). "Shugoshin Prevents Dissociation of Cohesin from Centromeres During Mitosis in Vertebrate Cells". PLoS Biol. 3 (3): e86. doi:10.1371/journal.pbio.0030086. PMC 1054882. PMID 15737064.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Losada A, Yokochi T, Hirano T (2006). "Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts". J. Cell. Sci. 118 (Pt 10): 2133–41. doi:10.1242/jcs.02355. PMID 15855230.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.