STMN2

Stathmin 2
Identifiers
Symbols	STMN2 ; SCG10; SCGN10
External IDs	OMIM: 600621 MGI: 98241 HomoloGene: 5102 GeneCards: STMN2 Gene
Gene ontology Molecular function • protein binding • tubulin binding • calcium-dependent protein binding Cellular component • cytoplasm • endosome • Golgi apparatus • membrane • lamellipodium • axon • growth cone • vesicle • neuron projection • neuronal cell body • perinuclear region of cytoplasm Biological process • microtubule depolymerization • negative regulation of microtubule depolymerization • positive regulation of neuron projection development • negative regulation of neuron projection development • negative regulation of microtubule polymerization • positive regulation of microtubule depolymerization • neuron projection development • cellular response to nerve growth factor stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11075	20257
Ensembl	ENSG00000104435	ENSMUSG00000027500
UniProt	Q93045	P55821
RefSeq (mRNA)	NM_001199214	NM_025285
RefSeq (protein)	NP_001186143	NP_079561
Location (UCSC)	Chr 8: 79.61 – 79.67 Mb	Chr 3: 8.51 – 8.56 Mb
PubMed search

Stathmin-2 is a protein that in humans is encoded by the STMN2 gene.^[1][2][3]

Superior cervical ganglion-10 is a neuronal growth-associated protein which shares significant amino acid sequence similarity with the phosphoprotein stathmin (MIM 151442).[supplied by OMIM]^[3]

Interactions

STMN2 has been shown to interact with RGS6.^[2]

References

1. Okazaki T, Wang H, Masliah E, Cao M, Johnson SA, Sundsmo M, Saitoh T, Mori N (June 1996). "SCG10, a neuron-specific growth-associated protein in Alzheimer's disease". Neurobiol Aging 16 (6): 883–94. doi:10.1016/0197-4580(95)02001-2. PMID 8622778.
2. Liu Z, Chatterjee TK, Fisher RA (September 2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". J Biol Chem 277 (40): 37832–9. doi:10.1074/jbc.M205908200. PMID 12140291.
3. "Entrez Gene: STMN2 stathmin-like 2".

Further reading

• Di Paolo G, Lutjens R, Pellier V, et al. (1997). "Targeting of SCG10 to the area of the Golgi complex is mediated by its NH2-terminal region". J. Biol. Chem. 272 (8): 5175–82. doi:10.1074/jbc.272.8.5175. PMID 9030585.
• Antonsson B, Lütjens R, Di Paolo G, et al. (1997). "Purification, characterization, and in vitro phosphorylation of the neuron-specific membrane-associated protein SCG10". Protein Expr. Purif. 9 (3): 363–71. doi:10.1006/prep.1996.0710. PMID 9126608.
• Antonsson B, Kassel DB, Di Paolo G, et al. (1998). "Identification of in vitro phosphorylation sites in the growth cone protein SCG10. Effect Of phosphorylation site mutants on microtubule-destabilizing activity". J. Biol. Chem. 273 (14): 8439–46. doi:10.1074/jbc.273.14.8439. PMID 9525956.
• Lutjens R, Igarashi M, Pellier V, et al. (2000). "Localization and targeting of SCG10 to the trans-Golgi apparatus and growth cone vesicles". Eur. J. Neurosci. 12 (7): 2224–34. doi:10.1046/j.1460-9568.2000.00112.x. PMID 10947801.
• Neidhart S, Antonsson B, Gilliéron C, et al. (2001). "c-Jun N-terminal kinase-3 (JNK3)/stress-activated protein kinase-beta (SAPKbeta) binds and phosphorylates the neuronal microtubule regulator SCG10". FEBS Lett. 508 (2): 259–64. doi:10.1016/S0014-5793(01)03090-3. PMID 11718727.
• Nixon AB, Grenningloh G, Casey PJ (2002). "The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly". J. Biol. Chem. 277 (20): 18127–33. doi:10.1074/jbc.M201065200. PMID 11882662.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Greka A, Navarro B, Oancea E, et al. (2003). "TRPC5 is a regulator of hippocampal neurite length and growth cone morphology". Nat. Neurosci. 6 (8): 837–45. doi:10.1038/nn1092. PMID 12858178.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kuwabara T, Hsieh J, Nakashima K, et al. (2004). "A small modulatory dsRNA specifies the fate of adult neural stem cells". Cell 116 (6): 779–93. doi:10.1016/S0092-8674(04)00248-X. PMID 15035981.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gocke CB, Yu H, Kang J (2005). "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates". J. Biol. Chem. 280 (6): 5004–12. doi:10.1074/jbc.M411718200. PMID 15561718.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Lee HS, Lee DC, Park MH, et al. (2006). "STMN2 is a novel target of beta-catenin/TCF-mediated transcription in human hepatoma cells". Biochem. Biophys. Res. Commun. 345 (3): 1059–67. doi:10.1016/j.bbrc.2006.05.017. PMID 16712787.
• Manna T, Grenningloh G, Miller HP, Wilson L (2007). "Stathmin family protein SCG10 differentially regulates the plus and minus end dynamics of microtubules at steady state in vitro: implications for its role in neurite outgrowth". Biochemistry 46 (11): 3543–52. doi:10.1021/bi061819d. PMID 17311410.